1391736-87-0Relevant articles and documents
Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: Development of a highly selective and more potent in vitro probe
Delpire, Eric,Baranczak, Aleksandra,Waterson, Alex G.,Kim, Kwangho,Kett, Nathan,Morrison, Ryan D.,Scott Daniels,David Weaver,Lindsley, Craig W.
experimental part, p. 4532 - 4535 (2012/08/08)
Further chemical optimization of the MLSCN/MLPCN probe ML077 (KCC2 IC 50 = 537 nM) proved to be challenging as the effort was characterized by steep SAR. However, a multi-dimensional iterative parallel synthesis approach proved productive. Here
