1391851-21-0

Basic information

• Product Name: C₂₂H₂₇ClN₂O₂
• Synonyms: C₂₂H₂₇ClN₂O₂
• CAS NO: 1391851-21-0
• Molecular Weight: 386.922
• Mol File: 1391851-21-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₂H₂₇ClN₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₂H₂₇ClN₂O₂(1391851-21-0)
• EPA Substance Registry System: C₂₂H₂₇ClN₂O₂(1391851-21-0)

Safety Data

• Hazardous Substances Data: 1391851-21-0(Hazardous Substances Data)

Upstream product

• 163837-57-8 (R)-(4-chlorophenyl)(phenyl)methylamine 

Downstream Products

• 130018-87-0 levocetirizine dihydrochloride 
• 130018-77-8 levocetirizine 
• 300543-56-0 (R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine 
• 1177093-13-8 C₁₉H₂₃ClN₂O*ClH 

Relevant articles and documents

AN IMPROVED PROCESS FOR THE PREPARATION OF ANTIHISTAMINIC DRUGS VIA A NOVEL CARBAMATE INTERMEDIATE

The present invention relates to a novel racemic or optically active carbamate intermediate of formula (IV A). This novel racemic or optically active carbamate intermediate of formula (IV A) can be used to prepare drugs having antihistaminic activity such as cetirizine (IA), meclizine (IB), chlorcyclizine (IC), clocinizine (ID), buclizine (IE) and enantiomers thereof such as levocetirizine (I). Further, disclosed herein is an improved process for the preparation of levocetirizine via a novel optically active intermediate i.e. compound of formula (IV). Also, disclosed herein is a novel process for the preparation of compound (II) and for crystallization of its salt.