1177093-13-8

Basic information

• Product Name: 4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride
• Synonyms: 4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride
• CAS NO: 1177093-13-8
• Molecular Formula: C19H24Cl2N2O
• Molecular Weight: 367.31266
• Mol File: 1177093-13-8.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride(1177093-13-8)
• EPA Substance Registry System: 4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride(1177093-13-8)

Safety Data

• Hazardous Substances Data: 1177093-13-8(Hazardous Substances Data)

Upstream product

• 103-76-4 1-(2-hydroxyethyl)piperazine 
• 134-83-8 1-chloro-4-(chloro(phenyl)methyl)benzene 
• 119-56-2 (4-chlorophenyl)phenylmethanol 
• 134-85-0 4-chlorobenzophenone 
• 107-07-3 2-chloro-ethanol 
• 300543-56-0 (R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine 
• 163837-57-8 (R)-(4-chlorophenyl)(phenyl)methylamine 
• 1391851-21-0 C₂₂H₂₇ClN₂O₂ 
• 303-26-4 N-(4-chlorobenzhydryl)piperazine 

Relevant articles and documents

New manufacturing procedure of cetirizine

A new procedure for the manufacture of cetirizine dihydrochloride via the new intermediate 2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)- N,N-dimethylacetamide dihydrochloride, synthesized by O-alkylation of 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethanol with 2-chloro-N,N-dimethylacetamide, is elaborated. Hydrolysis of the resulting amide and subsequent salification provided cetirizine dihydrochloride.

NOVEL WATER BASED PROCESS FOR THE PREPARATION OF SUBSTITUTED DIPHENYLMETHYL PIPERAZINES

The present invention relates to a novel water based process for the preparation of substituted diphenylmethyl piperazines of Formula I and pharmaceutically acceptable salts wherein X1 and X2 represent independently a hydrogen, a halogen, a straight or branched chain lower alkyl, alkoxy or a hydroxyl radical and R is selected from groups such as acyl, alkyl, alkenyl, aralalkyl, aralalkenyl aralkyl, and aralalkenyl or aralkenyl hydroxyalkyl, aryloxyalkyl, alkoxyalkyl, aminoalkyl or its derivative comprising, reacting a compound of Formula II, with a compound of formula R—X where R is as defined above and X is suitable leaving group which includes halides, but not limiting use of other leaving groups such as tosylate, mesylate and activated acid groups such as acyl halide, anhydrides, mixed anhydrides etc. using water as a solvent, in presence of a catalyst and a base, at 25-100° C.;