1391986-79-0Relevant academic research and scientific papers
Metal free C-H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1
Thatikonda, Thanusha,Singh, Umed,Ambala, Srinivas,Vishwakarma, Ram A.,Singh, Parvinder Pal
, p. 4312 - 4320 (2016)
Here, we report a metal-free cross-coupling reaction of diazines and related heteroarenes with organoboron species via C-H functionalization. The optimized conditions represent a metal-free method for the activation of aryl/heteroarylboronic acids, which undergo coupling with diazines and related heteroarenes. Optimized conditions also find application in the synthesis of a pyrimidine-based potent CDK inhibitor, meriolin1.
Regioselective synthesis of trialkylpyrazines via nickel-catalyzed Negishi cross-coupling of pyrazine triflate
Pitchaiah, Arigala,Hwang, Intaek,Hwang, Jin-Soo,Kim, Hyungrok,Lee, Kee-In
, p. 1631 - 1636 (2012/06/30)
A regioselective synthesis of trialkylpyrazines via nickel-catalyzed cross-coupling reaction of pyrazine triflate is reported. The 5-substituted 2,3-dimethylpyrazine derivatives including trail pheromone components of the ant Eutetramorium mocquerysi have been successfully synthesized in good yields by nickel-catalyzed Negishi cross-coupling reactions of pyrazine triflate mediated by alkyl and arylzinc halides. Georg Thieme Verlag Stuttgart · New York.
