Cas 1392102-34-9,C<sub>21</sub>H<sub>12</sub>BrClFNO

1392102-34-9

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Basic information

Product Name: C₂₁H₁₂BrClFNO
Synonyms: C₂₁H₁₂BrClFNO
CAS NO:1392102-34-9
Molecular Formula:
Molecular Weight: 428.688
EINECS: N/A
Product Categories: N/A

Chemical Properties

Melting Point: N/A
Boiling Point: N/A
Flash Point: N/A
Appearance: N/A
Density: N/A
Refractive Index: N/A
Storage Temp.: N/A
Solubility: N/A
CAS DataBase Reference: C₂₁H₁₂BrClFNO(CAS DataBase Reference)
NIST Chemistry Reference: C₂₁H₁₂BrClFNO(1392102-34-9)
EPA Substance Registry System: C₂₁H₁₂BrClFNO(1392102-34-9)

Safety Data

Hazard Codes: N/A
Statements: N/A
Safety Statements: N/A
WGK Germany:
RTECS:
HazardClass: N/A
PackingGroup: N/A
Hazardous Substances Data: 1392102-34-9(Hazardous Substances Data)

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Check Digit Verification of cas no

The CAS Registry Mumber 1392102-34-9 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,2,1,0 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1392102-34:
(9*1)+(8*3)+(7*9)+(6*2)+(5*1)+(4*0)+(3*2)+(2*3)+(1*4)=129
129 % 10 = 9
So 1392102-34-9 is a valid CAS Registry Number.

1392102-34-9Upstream product

1392102-34-9Downstream Products

1392102-34-9Relevant academic research and scientific papers

Structure–activity relationships of proline modifications around the tetracyclic-indole class of NS5A inhibitors

Tong, Ling,Yu, Wensheng,Coburn, Craig A.,Chen, Lei,Selyutin, Oleg,Zeng, Qingbei,Dwyer, Michael P.,Nair, Anilkumar G.,Shankar, Bandarpalle B.,Kim, Seong Heon,Yang, De-Yi,Rosenblum, Stuart B.,Ruck, Rebecca T.,Davies, Ian W.,Hu, Bin,Zhong, Bin,Hao, Jinglai,Ji, Tao,Zan, Shuai,Liu, Rong,Agrawal, Sony,Carr, Donna,Curry, Stephanie,McMonagle, Patricia,Bystol, Karin,Lahser, Frederick,Ingravallo, Paul,Chen, Shiying,Asante-Appiah, Ernest,Kozlowski, Joseph A.

, p. 5354 - 5360 (2016/10/30)

We describe the impact of proline modifications, in our tetracyclic-indole based series of nonstructural protein 5A (NS5A) inhibitors, to their replicon profiles. This work identified NS5A inhibitors with an improved and flattened resistance profiles.

Substituted tetracyclic indole core derivatives of HCV NS5A inhibitor MK-8742

Yu, Wensheng,Zhou, Guowei,Coburn, Craig A.,Zeng, Qingbei,Tong, Ling,Dwyer, Michael P.,Hu, Bin,Zhong, Bin,Hao, Jinglai,Ji, Tao,Zan, Shuai,Chen, Lei,Mazzola, Robert,Kim, Jae-Hun,Sha, Deyou,Selyutin, Oleg,Rosenblum, Stuart B.,Lavey, Brian,Nair, Anilkumar G.,Heon Kim, Seong,Keertikar, Kerry M.,Rokosz, Laura,Agrawal, Sony,Liu, Rong,Xia, Ellen,Zhai, Ying,Curry, Stephanie,McMonagle, Patricia,Ingravallo, Paul,Asante-Appiah, Ernest,Chen, Shiying,Kozlowski, Joseph A.

, p. 4851 - 4856 (2016/09/13)

As part of an ongoing effort in NS5A inhibition at Merck we now describe our efforts for introducing substitution around the tetracyclic indole core of MK-8742. Fluoro substitution on the core combined with the fluoro substitutions on the proline ring improved the potency against GT1a Y93H significantly. However, no improvement on GT2b potency was achieved. Limiting the fluoro substitution to C-1 of the tetracyclic indole core had a positive impact on the potency against the resistance associated variants, such as GT1a Y93H and GT2b, and the PK profile as well. Compounds, such as 62, with reduced potency shifts between wild type GT1a to GT2b, GT1a Y93H, and GT1a L31V were identified.

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