1392191-08-0

Basic information

• Product Name: 5,7-dimethoxy-4-methyl-3-phenylquinolin-2(1H)-one
• Synonyms: 5,7-dimethoxy-4-methyl-3-phenylquinolin-2(1H)-one
• CAS NO: 1392191-08-0
• Molecular Weight: 295.338
• Mol File: 1392191-08-0.mol

Chemical Properties

• CAS DataBase Reference: 5,7-dimethoxy-4-methyl-3-phenylquinolin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dimethoxy-4-methyl-3-phenylquinolin-2(1H)-one(1392191-08-0)
• EPA Substance Registry System: 5,7-dimethoxy-4-methyl-3-phenylquinolin-2(1H)-one(1392191-08-0)

Safety Data

• Hazardous Substances Data: 1392191-08-0(Hazardous Substances Data)

Upstream product

• 776313-19-0 N-(2-acetyl-3,5-dimethoxyphenyl)benzylamide 
• 256642-33-8 2′-amino-4′,6′-dimethoxyacetophenone 
• 103-82-2 phenylacetic acid 

Downstream Products

• 1392191-16-0 5,7-dihydroxy-4-methyl-3-phenylquinolin-2(1H)-one 
• 1392191-15-9 5-hydroxy-7-methoxy-4-methyl-3-phenylquinolin-2(1H)-one 
• 1392191-14-8 7-hydroxy-5-methoxy-4-methyl-3-phenylquinolin-2(1H)-one 

Relevant articles and documents

NOVEL AZACOUMARIN DERIVATIVES HAVING MDR PUMP INHIBITING ACTIVITY

The present invention relates to compounds of formula (I), where R1 and R2, identical or different, are each independently a hydrogen atom or a non-substituted or substituted (C1-C12) alkyl group; R3 is a hydrogen atom or a non-substituted or substituted (C1-C6) alkyl group; R4 is a non-substituted or substituted (C1-C12) alkyl group or an aryl or heteroaryl group, said aryl and heteroaryl groups being non-substituted or substituted; and R5 is a non-substituted or substituted (C1-C12) alkyl group; or R4 and R5 are bonded to one another by a saturated hydrocarbon chain having 3 or 4 carbon atoms, optionally in hydrated form or in the form of a salt that is acceptable for being administered to animals or plants, for the use thereof as a potentiator of the effect of an antimicrobial agent or for the use thereof as an antimicrobial agent.

3-Aryl-4-methyl-2-quinolones Targeting Multiresistant Staphylococcus aureus Bacteria

The NorA efflux pump lowers intracellular fluoroquinolone concentrations by expelling antibiotics through the membrane of Staphylococcus aureus. We identified 3-aryl-4-methyl-2-quinolin-2-ones as compounds able to restore the activity of the NorA substrate, ciprofloxacin, against resistant S.aureus strains, and acting as efflux pump inhibitors (EPI). In particular, 5-hydroxy-7-methoxy-4-methyl-3-phenylquinolin-2-one (6c) presents both an EPI and an antimicrobial effect. Its efficacy and safety make it a potential candidate for further investigations.