776313-19-0

Basic information

• Product Name: N-(2-acetyl-3,5-dimethoxyphenyl)benzylamide
• Synonyms: N-(2-acetyl-3,5-dimethoxyphenyl)benzylamide
• CAS NO: 776313-19-0
• Molecular Weight: 313.353
• Mol File: 776313-19-0.mol

Chemical Properties

• CAS DataBase Reference: N-(2-acetyl-3,5-dimethoxyphenyl)benzylamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-acetyl-3,5-dimethoxyphenyl)benzylamide(776313-19-0)
• EPA Substance Registry System: N-(2-acetyl-3,5-dimethoxyphenyl)benzylamide(776313-19-0)

Safety Data

• Hazardous Substances Data: 776313-19-0(Hazardous Substances Data)

Upstream product

• 10272-07-8 3.5-dimethoxyaniline 
• 103-82-2 phenylacetic acid 
• 256642-33-8 2′-amino-4′,6′-dimethoxyacetophenone 

Downstream Products

• 1392191-08-0 5,7-dimethoxy-4-methyl-3-phenylquinolin-2(1H)-one 

Relevant articles and documents

3-Aryl-4-methyl-2-quinolones Targeting Multiresistant Staphylococcus aureus Bacteria

The NorA efflux pump lowers intracellular fluoroquinolone concentrations by expelling antibiotics through the membrane of Staphylococcus aureus. We identified 3-aryl-4-methyl-2-quinolin-2-ones as compounds able to restore the activity of the NorA substrate, ciprofloxacin, against resistant S.aureus strains, and acting as efflux pump inhibitors (EPI). In particular, 5-hydroxy-7-methoxy-4-methyl-3-phenylquinolin-2-one (6c) presents both an EPI and an antimicrobial effect. Its efficacy and safety make it a potential candidate for further investigations.

Antimitotic activity of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones

We report the synthesis of 5-hydroxy-7-methoxy-2-phenyl-4-quinolones and their biological activity as antitumor agents. These molecules were initially evaluated for their ability to induce cell cycle arrest in the G2/M phase. Compounds that showed signifi