1392201-04-5Relevant articles and documents
Design, synthesis and antiproliferative activity of novel 2-substituted-4-amino-6-halogenquinolines
Jiang, Nan,Zhai, Xin,Li, Ting,Liu, Difa,Zhang, Tingting,Wang, Bin,Gong, Ping
, p. 5870 - 5881 (2012/09/22)
Two series of novel 2-substituted-4-amino-6-halogenquinolines 8a-l and 13a-h were designed, synthesized and evaluated for their antiproliferative activity against H-460, HT-29, HepG2 and SGC-7901 cancer cell lines in vitro. The pharmacological results indicated that most compounds with 2-arylvinyl substituents exhibited good to excellent antiproliferative activity. Among them, compound 8e was a considered promising lead for further structural modifications with IC50 values of 0.03 μM, 0.55 μM, 0.33 μM and 1.24 μM, which was 2.5- to 186-fold more active than gefitinib and compound 1.