1392201-16-9

Basic information

• Product Name: 6-fluoro-2-(((4-methylphenyl)sulfonyl)methyl)-N-(3-morpholin-4ylpropyl)quinolin-4-amine
• CAS NO: 1392201-16-9
• Molecular Weight: 457.569
• Mol File: 1392201-16-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-fluoro-2-(((4-methylphenyl)sulfonyl)methyl)-N-(3-morpholin-4ylpropyl)quinolin-4-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 6-fluoro-2-(((4-methylphenyl)sulfonyl)methyl)-N-(3-morpholin-4ylpropyl)quinolin-4-amine(1392201-16-9)
• EPA Substance Registry System: 6-fluoro-2-(((4-methylphenyl)sulfonyl)methyl)-N-(3-morpholin-4ylpropyl)quinolin-4-amine(1392201-16-9)

Safety Data

• Hazardous Substances Data: 1392201-16-9(Hazardous Substances Data)

Upstream product

• 371-40-4 4-fluoroaniline 
• 15912-68-2 6-fluoro-2-methylquinolin-4-ol 
• 1392200-84-8 C₁₂H₁₄FNO₂ 
• 1392201-03-4 C₁₇H₁₃ClFNS 
• 1392200-82-6 4-chloro-2-(chloromethyl)-6-fluoroquinoline 
• 1392200-81-5 4-chloro-6-fluoro-2-methylquinoline 1-oxide 
• 18529-01-6 4-chloro-6-fluoro-2-methylquinoline 
• 123-00-2 4-(3-Aminopropyl)morpholine 
• 1392201-07-8 C₁₇H₁₃ClFNO₂S 

Relevant articles and documents

Design, synthesis and antiproliferative activity of novel 2-substituted-4-amino-6-halogenquinolines

Two series of novel 2-substituted-4-amino-6-halogenquinolines 8a-l and 13a-h were designed, synthesized and evaluated for their antiproliferative activity against H-460, HT-29, HepG2 and SGC-7901 cancer cell lines in vitro. The pharmacological results indicated that most compounds with 2-arylvinyl substituents exhibited good to excellent antiproliferative activity. Among them, compound 8e was a considered promising lead for further structural modifications with IC50 values of 0.03 μM, 0.55 μM, 0.33 μM and 1.24 μM, which was 2.5- to 186-fold more active than gefitinib and compound 1.