139229-99-5Relevant academic research and scientific papers
Design, synthesis and evaluation of potent G-protein coupled receptor 40 agonists
Huang, Jing,Guo, Bin,Chu, Wen-Jing,Xie, Xin,Yang, Yu-She,Zhou, Xian-Li
, p. 159 - 162 (2016)
GPR40 has emerged as an attractive drug target for the treatment of type 2 diabetes due to its role in the enhancement of insulin secretion with glucose dependency. With the aim to improve the metabolic and safety profiles, a series of novel phenylpropionic acid derivatives were synthesized. Extensive structural optimization led to identification of compounds 22g and 23e as potent GPR40 agonists with moderate liver microsomal stability. All the discovery supported further exploration surrounding this scaffold.
LIPID PRODRUGS OF NEUROSTEROIDS
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Paragraph 00462-00463, (2021/08/13)
The present invention provides lymphatic system-directing lipid prodrugs, pharmaceutical compositions thereof, methods of producing such prodrugs and compositions, as well as methods of improving the bioavailability or other properties of a therapeutic agent that comprises part of the lipid prodrug. The present invention also provides methods of treating a disease, disorder, or condition such as those disclosed herein, comprising administering to a patient in need thereof a disclosed lipid prodrug or a pharmaceutical composition thereof.
Organic synthesis using a hypervalent iodine reagent: Unexpected and novel domino reaction leading to spiro cyclohexadienone lactones
Fujioka, Hiromichi,Komatsu, Hideyuki,Nakamura, Taeko,Miyoshi, Akihito,Hata, Kayoko,Ganesh, Jnashuara,Murai, Kenichi,Kita, Yasuyuki
supporting information; scheme or table, p. 4133 - 4135 (2010/09/03)
The reaction of 1-(p-hydroxyaryl)cyclobutanols and phenyl iodide(iii) diacetate in hexafluoroisopropanol and water produced spiro cyclohexadienone lactones via a domino reaction.
A dual sensor spin trap for use with EPR spectroscopy
Caldwell, Stuart T.,Quin, Caroline,Edge, Ruth,Hartley, Richard C.
, p. 3499 - 3502 (2008/02/12)
Redox active metal ions, carbon-centered radicals, and oxygen-centered radicals are important to oxidative stress. A radical detector combining a nitrone spin trap, a phenol, and a cyclopropane radical clocklike unit was prepared and used with EPR spectroscopy to detect and distinguish between hydroxyl radicals, methyl radicals, and iron(III) ions. Iron(III) reacts with the phenol unit inducing opening of the cyclopropane ring and cyclization to generate a stable nitroxyl radical.
