139240-50-9

Upstream product

• 671782-19-7 [1-(4-methylphenyl)ethylidene]cyclopropane 
• 139167-01-4 (S)-(-)-2-(hydroxymethyl)-2-(p-tolyl)cyclobutanone 
• 139167-12-7 (tert-butyldiphenylsiloxy)methyl p-tolyl ketone 
• 139166-93-1 2-cyclopropylidene-2-(p-tolyl)-1-ethanol 
• 139167-26-3 (R)-(+)-2-<(phenylthio)methyl>-2-(p-tolyl)cyclobutanone 
• 139167-23-0 tert-Butyl-(2-cyclopropylidene-2-p-tolyl-ethoxy)-diphenyl-silane 
• 139167-08-1 2-(tert-butyldiphenylsiloxy)-1-(p-tolyl)-1-ethanol 

Downstream Products

• 145800-57-3 (1R,2S)-2-methyl-2-p-tolyl-1-vinylcyclobutanol 
• 145842-56-4 (1S,2S)-2-methyl-2-p-tolyl-1-vinylcyclobutanol 
• 152094-61-6 (1S,2S)-2-Methyl-2-p-tolyl-cyclobutanol 
• 145842-58-6 (1S,2S)-2-methyl-2-p-tolyl-1-triethylsiloxy-1-vinylcyclobutane 
• 145800-60-8 (1R,2S)-2-methyl-2-p-tolyl-1-triethylsiloxy-1-vinylcyclobutane 
• 145842-59-7 (1S,3S)-3-methyl-2-methylene-3-p-tolylcyclopentanol 
• 145800-61-9 (1R,3S)-3-methyl-2-methylene-3-p-tolylcyclopentanol 
• 145800-58-4 (1S,2S)-1-(1,2-epoxyethyl)-2-methyl-2-p-tolylcyclobutanol 
• 145800-58-4 (1R,2S)-1-(1,2-epoxyethyl)-2-methyl-2-p-tolylcyclobutanol 
• 145800-62-0 (1S,3S)-3-methyl-2-methylene-3-p-tolylcyclopentyl benzoate 
• 145800-63-1 (1S,2R,3S)-2,3-dimethyl-3-p-tolylcyclopentyl benzoate 
• 145842-60-0 (1S,2R,3S)-2,3-dimethyl-3-p-tolylcyclopentanol 
• 93862-62-5 (3S)-3-methyl-2-methylene-3-p-tolylcyclopentanone 
• 130398-94-6 (1R)-1,2-dimethyl-1-p-tolylcyclopentane 

Relevant academic research and scientific papers

Enantioselective synthesis of γ-aryl-γ-butyrolactones by sequential asymmetric epoxidation, ring expansion, and Baeyer-Villiger oxidation

(Chemical Equation Presented) This paper describes an enantioselective synthesis of γ-butyrolactones, using the N-tolyl-substituted oxazolidinone-containing ketone as catalyst and Oxone as oxidant via a sequential asymmetric epoxidation of benzylidenecyclopropanes, ring expansion, and Baeyer-Villiger oxidation. Up to 91% ee was obtained. Optically active cyclobutanones can also be obtained by suppressing the Baeyer-Villiger oxidation with use of more ketone catalyst and less Oxone.

A Concise and Enantioselective Approach to Cyclobutanones by Tandem Asymmetric Epoxidation and Enantiospecific Ring Expansion of Cyclopropylidene Alcohols. An Enantiocontrolled Synthesis of (+)- and (-)-α-Cuparenones

A tandem Katsuki-Sharpless asymmetric epoxidation and enantiospecific ring expansion of 2-alkyl(or 2-aryl)-2-cyclopropylideneethanols (1a-i) afforded chiral 1-alkyl(or 1-aryl)-1-(hydroxymethyl)cyclobutanones (3a-i) in high yields and high enantiomeric excess.These compounds are potentially valuable synthons for the enantioselective creation of the quaternary carbons.Hence, this enabled us to accomplish a concise and enantioselective total synthesis of both (+)- and (-)-cuparenones (11).