139244-01-2

Upstream product

• 73349-28-7 sodium salt of 6-chloropurine 
• 4330-21-6 2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride 
• 452-51-7 D-2-deoxyribose 

Downstream Products

• 773133-81-6 6-(benzoyloxymethyl)-9-(2-deoxy-3,5-di-O-toluoyl-β-D-erythro-pentofuranosyl)purine 
• 773133-74-7 6-(pivaloyloxymethyl)-9-(2-deoxy-3,5-di-O-toluoyl-β-D-erythro-pentofuranosyl)purine 
• 773133-85-0 6-(hydroxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluolyl)-β-D-erythro-pentofuranosyl)purine 
• 773133-86-1 6-(acetyloxymethyl)-9-(2-deoxy-3,5-di-O-(p-toluolyl)-β-D-erythro-pentofuranosyl)purine 

Relevant academic research and scientific papers

Pentenyl Ribosides: New Reagents for Purine Nucleoside Synthesis

Protected pent-4-enyl ribosides and deoxyribosides were synthesized as reagents for the preparation of nucleosides and deoxynucleosides.Reaction of pent-4-enyl 2',3',5'-tri-O-benzoyl-D-erythro-pentofuranoside with five nucleobases in the presence of N-iod

FACILE STEREOSPECIFIC SYNTHESIS OF α-ANOMERIC 2'-DEOXYNUCLEOSIDES

The coupling reaction of activated nucleobases, such as the sodium salts of N-benzoyladenine and 6-chloropurine and 2,4-bis-O-trimethylsilylthymine, with 1-α-chloro-2-deoxy-3,5-di-O-p-toluoylribofuranose (1) in a mixture of acetonitrile and tetrahydrofuran leads to the stereospecific formation of α-anomeric 2'-deoxynucleosides with satisfactory yields.The ratio of the distribution between the resulted α- and β-stereoisomers was about 3:1 in each case.The method is simple and applicable to the preparation of both purine and pyrimidine α-2'-deoxynucleosides.