139244-08-9

Upstream product

• 103-79-7 1-phenyl-acetone 
• 535-11-5 Ethyl 2-bromopropionate 
• 127229-64-5 Ethyl 2-chloro-2,3-dimethyl-3-butenoate 
• 591-51-5 phenyllithium 
• 3699-66-9 ethyl 2-diethoxyphosphorylpropionate 
• 698-87-3 3-phenyl-2-propanol 
• 535-13-7 2-chloro-propanoic acid, ethyl ester 

Downstream Products

• 34599-63-8 2,3-dimethyl-4-phenylbutanoic acid 
• 855153-25-2 2,3-dimethyl-4-phenyl-butyric acid ethyl ester 

Relevant academic research and scientific papers

Agent for reduction of sensory irritation

Provision of a TRPA1 activity inhibitor capable of reducing sensory irritation to skin or mucous membrane and an agent for reduction of sensory irritation for skin or mucous membrane. A TRPA1 inhibitor and an agent for reduction of sensory irritation for skin or mucous membrane comprising as an active ingredient a compound represented by the following formula (1) wherein R1 and R3 each independently represent a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, R2 represents an alkyl group having 1 to 6 carbon atoms, R4 represents a hydrogen atom, a methyl group or an ethyl group, and a double line composed of a dotted line and a solid line represents a single bond or a double bond.

Synthesis of (E)-α,β-unsaturated esters with total or high diastereoselectivity from α,β-epoxyesters

Chemical equation presented High stereoselective β-elimination in 2,3-epoxyesters 1 was achieved using samarium diiodide, yielding α,β-unsaturated esters 2, in which the C=C bond is di-, tri- or tetrasubstituted. The starting compounds 1 are easily prepared by reaction of the corresponding lithium enolates of a-chloroesters with aldehydes or ketones at -78 °C. The influence of the reaction conditions and the structure of the starting compounds in the stereoselectivity of the β-elimination reaction is also discussed.