1392480-36-2Relevant academic research and scientific papers
Noncovalent organocatalytic synthesis of enantioenriched terminal aziridines with a quaternary stereogenic center
De Fusco, Claudia,Fuoco, Tiziana,Croce, Gianluca,Lattanzi, Alessandra
, p. 4078 - 4081 (2012/09/21)
A high-yielding and enantioselective access to novel N-Boc terminal aziridines, bearing a quaternary stereogenic center, has been developed via an aza-Michael initiated ring-closure (aza-MIRC) reaction of α-acyl acrylates with an N-tosyloxy tert-butyl carbamate catalyzed by a chiral amino thiourea. The feasibility of the aziridine regioselective ring-opening to valuable α,α-disubstituted α-amino acid esters has been demonstrated.
