1392482-82-4

Basic information

• Product Name: 4-[3-oxo-3-(2-phenylamino-pyridin-3-yl)-propyl]-benzoic acid methyl ester
• Synonyms: 4-[3-oxo-3-(2-phenylamino-pyridin-3-yl)-propyl]-benzoic acid methyl ester
• CAS NO: 1392482-82-4
• Molecular Weight: 360.412
• Mol File: 1392482-82-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-[3-oxo-3-(2-phenylamino-pyridin-3-yl)-propyl]-benzoic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[3-oxo-3-(2-phenylamino-pyridin-3-yl)-propyl]-benzoic acid methyl ester(1392482-82-4)
• EPA Substance Registry System: 4-[3-oxo-3-(2-phenylamino-pyridin-3-yl)-propyl]-benzoic acid methyl ester(1392482-82-4)

Safety Data

• Hazardous Substances Data: 1392482-82-4(Hazardous Substances Data)

Upstream product

• 55676-21-6 3-acetyl-2-chloropyridine 
• 2942-59-8 2-chloronicotinic acid 
• 1080675-01-9 1-(2-phenylamino-pyridin-3-yl)-ethanone 
• 1392482-81-3 4-[(E)-3-oxo-3-(2-phenylamino-pyridin-3-yl)-propenyl]-benzoic acid methyl ester 
• 62-53-3 aniline 
• 488149-34-4 2-chloro-N-methoxy-N-methyl-pyridine-3-carboxamide 

Downstream Products

• 1392482-83-5 4-{3-[2-(methoxyoxalyl-phenyl-amino)-pyridin-3-yl]-3-oxo-propyl}benzoic acid methyl ester 
• 1392482-84-6 3-(4-carboxy-benzyl)-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester 
• 1392482-80-2 3-[4-(1-hydroxymethyl-cyclopropylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester 
• 1392482-79-9 3-[4-(2-hydroxy-1,1-dimethyl-ethylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester 
• 1392482-77-7 3-[4-(2-hydroxy-2-methyl-propylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester 
• 1392482-75-5 3-[4-((S)-1-hydroxymethyl-2,2-dimethyl-propylcarbamoyl)-benzyl]-4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester 

Relevant articles and documents

Identification of an adamantyl azaquinolone JNK selective inhibitor

3-[4-((1S,2S,3R,5S,7S)-5-Hydroxyadamantan-2-ylcarbamoyl)benzyl] -4-oxo-1-phenyl-1,4-dihydro-[1,8]naphthyridine-2-carboxylic acid methyl ester (4) was identified as a novel, druglike and selective quinolone pan JNK inhibitor. In this communication, some of the structure-activity relationship of the azaquinolone analogues leading to 4 is discussed. The focus is on how changes at the amide functionality affected the biochemical potency, cellular potency, metabolic properties, and solubility of this class of JNK inhibitors. Optimization of these properties led to the identification of the adamantyl analogue, 4. 4 achieved proof of mechanism in both rat and mouse TNF-α challenge models.