139253-79-5

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-BROMO-N,N DIMETHYL BENZAMIDE is used as a chemical intermediate for the synthesis of various drugs. Its unique structure and properties allow it to be incorporated into the development of new pharmaceutical compounds, contributing to the advancement of medicinal chemistry.
Used in Organic Synthesis:
In the field of organic synthesis, 2-AMINO-5-BROMO-N,N DIMETHYL BENZAMIDE serves as a reagent, facilitating the formation of new chemical entities. Its presence in reactions can lead to the creation of diverse organic compounds, expanding the scope of chemical research and development.
Used in Biochemistry Research:
As a research tool in biochemistry, 2-AMINO-5-BROMO-N,N DIMETHYL BENZAMIDE is utilized to study biological processes and mechanisms. Its interaction with biological systems can provide insights into the molecular basis of various biological activities, aiding in the discovery of novel therapeutic targets and approaches.

Upstream product

• 4692-98-2 5-bromoisatoic anhydride 
• 506-59-2 N,N-dimethylammonium chloride 
• 124-40-3 dimethyl amine 
• 5794-88-7 5-Bromo-2-aminobenzoic acid 

Relevant academic research and scientific papers

Discovery of Spiro-azaindoline Inhibitors of Hematopoietic Progenitor Kinase 1 (HPK1)

Hematopoietic progenitor kinase 1 (HPK1) is implicated as a negative regulator of T-cell receptor-induced T-cell activation. Studies using HPK1 kinase-dead knock-in animals have demonstrated the loss of HPK1 kinase activity resulted in an increase in T-cell function and tumor growth inhibition in glioma models. Herein, we describe the discovery of a series of small molecule inhibitors of HPK1. Using a structure-based drug design approach, the kinase selectivity of the molecules was significantly improved by inducing and stabilizing an unusual P-loop folded binding mode. The metabolic liabilities of the initial 7-azaindole high-throughput screening hit were mitigated by addressing a key metabolic soft spot along with physicochemical property-based optimization. The resulting spiro-azaindoline HPK1 inhibitors demonstrated improved in vitro ADME properties and the ability to induce cytokine production in primary human T-cells.

METHODS AND COMPOUNDS FOR RESTORING MUTANT p53 FUNCTION

Mutations in oncogenes and tumor suppressors contribute to the development and progression of cancer. The present disclosure describes compounds and methods that restore DNA binding affinity of p53 mutants. The compounds of the present disclosure can bind to mutant p53 and restore the ability of the p53 mutant to bind DNA and activate downstream effectors involved in tumor suppression. The disclosed compounds can be used to reduce the progression of cancers that contain a p53 mutation.

MACROCYCLIC KINASE INHIBITORS

Compounds of Formula (I): wherein variables are defined herein, and pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers for which FAK inhibition is beneficial.

Pyrrolo-pyridine kinase modulators

The present invention provides novel pyrrolo-pyridine kinase modulators and methods of using the novel pyrrolo-pyridine kinase modulators to treat diseases mediated by kinase activity.