139258-91-6Relevant academic research and scientific papers
Synthesis and reactivity of ω-aldehydophosphoranes; application to the preparation of α,β-unsaturated lactones.
Floc'h, Y. Le,Yvergnaux, F.,Toupet, L.,Gree, R.
, p. 742 - 759 (2007/10/02)
α,β-Unsaturated lactones 1 (n = 1 to 7) and symmetrical unsaturated macrodiolides 2 are obtained by a Wittig reaction using ω-aldehydophosphoranes under high dilution conditions.The corresponding phosphonium salts are prepared in 3 steps from commercially available ω-diols.This methodology is applied to the synthesis of an unsaturated macrolide, a precursor of Patulolid A and Patulolid C. Key words: intramolecular Wittig reaction / ω-aldehydophosphoranes / unsaturated lactones / unsaturated dilactones
