139261-08-8Relevant articles and documents
Synthesis, acidity and 19F NMR characteristics of imidazoles bearing 1-fluorinated substituents with potential application as probes for intracellular pH determination.
Harper, Jacquie L.,Smith, Robin A. J.,Bedford, Jennifer J.,Leader, John P.
, p. 8211 - 8224 (2007/10/03)
A series of 1-substituted imidazoles containing fluorine have been prepared. These compounds were identified as potentially useful probes for intracellular pH determination based on 19F NMR. Key parameters including pK(a), 19F NMR chemical shift sensitivity, water solubility and low toxicity were identified and included in the target molecule selection process. The pK(a) and 19F NMR parameters of the molecules are reported and trends analysed.