139261-08-8Relevant academic research and scientific papers
Synthesis, acidity and 19F NMR characteristics of imidazoles bearing 1-fluorinated substituents with potential application as probes for intracellular pH determination.
Harper, Jacquie L.,Smith, Robin A. J.,Bedford, Jennifer J.,Leader, John P.
, p. 8211 - 8224 (2007/10/03)
A series of 1-substituted imidazoles containing fluorine have been prepared. These compounds were identified as potentially useful probes for intracellular pH determination based on 19F NMR. Key parameters including pK(a), 19F NMR chemical shift sensitivity, water solubility and low toxicity were identified and included in the target molecule selection process. The pK(a) and 19F NMR parameters of the molecules are reported and trends analysed.
Synthesis and Reactions of 1,2,4,5-Tetramethylimidazole; the Crystal Structure of Pentamethylimidazolium Iodide
Kuhn, Norbert,Henkel, Gerald,Kreutzberg, Joerg
, p. 1706 - 1712 (2007/10/02)
1,2,4,5-Tetramethylimidazole Derivatives, Synthesis, X-Ray1,2,4,5-Tetramethylimidazole (3) is obtained by metalation of 2,4,5-trimethylimidazole (2) with sodium in liquid ammonia and subsequent addition of methyl iodide. 3 reacts with Lewis acids to form the compounds Me4C3N2*BH3 (8) and Me4C3N2*E+ (4, 5, 7, 10; E = Me, H, SiMe3, C(O)Me).The X-ray structure reveals the ionic nature of pentamethylimidazolium iodide (4) in the solid state.
