139272-67-6

Basic information

• Product Name: Aceclofenac Ethyl Ester
• Synonyms: Aceclofenac Ethyl Ester;2-[(2,6-Dichlorophenyl)aMino]benzeneacetic Acid 2-Ethoxy-2-oxoethyl Ester;2-ethoxy-2-oxoethyl 2-(2-(2,6-dichlorophenylaMino)phenyl)acetate;Aceclofenac IMpurity–E(EP/BP);Aceclofenac EP IMpurity E;Ethyl [[[2-[(2,6-dichlorophenyl) amino] phenyl] acetyl] oxy] acetate
• CAS NO: 139272-67-6
• Molecular Formula: C18H17Cl2NO4
• Molecular Weight: 382.23788
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 139272-67-6.mol
• Article Data: 1

Chemical Properties

• Melting Point: 70-72°C
• Boiling Point: 460.501°C at 760 mmHg
• Flash Point: 232.303°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.596
• Storage Temp.: -20°C Freezer
• PKA: -2.84±0.50(Predicted)
• CAS DataBase Reference: Aceclofenac Ethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Aceclofenac Ethyl Ester(139272-67-6)
• EPA Substance Registry System: Aceclofenac Ethyl Ester(139272-67-6)

Safety Data

• Hazardous Substances Data: 139272-67-6(Hazardous Substances Data)

Usage

Description

Aceclofenac ethyl ester is a potential impurity found in commercial preparations of aceclofenac .

Chemical Properties

White Solid

InChI:InChI=1/C18H17Cl2NO4/c1-2-24-17(23)11-25-16(22)10-12-6-3-4-9-15(12)21-18-13(19)7-5-8-14(18)20/h3-9,21H,2,10-11H2,1H3

Upstream product

• 64-17-5 ethanol 
• 89796-99-6 aceclofenac 

Relevant articles and documents

Novel hybrids of drug with bioactive heterocycles for enhancing biological activity

A novel series of aceclofenac hybridised with 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazoles were designed using molecular hybridization approach and synthesised 6a–j. The structural integrity was confirmed by analytical methods. The hybrid molecules were subjected to in vitro cytotoxic studies against four human cancer cell lines PA‐1, OAW‐42, T47-D and MCF‐7 by MTT assay method. The results indicate that the hybrid molecules bearing halogen on phenyl ring in 6th position of triazolo-thiadiazole exhibited significant cytotoxic activity. The test compounds were also screened for antifungal activity against two strains.