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Usage

Uses

Used in Pharmaceutical Industry:
cis-Methyl 2,2-diMethyl-3-hydroxycyclobutanecarboxylate is used as a key intermediate in the synthesis of various pharmaceutical compounds for its ability to participate in multiple chemical reactions, contributing to the development of new drugs with potential therapeutic effects.
Used in Agrochemical Industry:
In the agrochemical sector, cis-Methyl 2,2-diMethyl-3-hydroxycyclobutanecarboxylate serves as a precursor in the production of certain agrochemicals, leveraging its reactivity to form compounds that can be used in pest control and crop protection.
Used in Organic Synthesis:
As a building block in organic synthesis, cis-Methyl 2,2-diMethyl-3-hydroxycyclobutanecarboxylate is utilized for the creation of a wide range of organic molecules and materials, taking advantage of its compact cyclic structure and high reactivity to form complex molecular architectures.
Used in Research and Development:
In research settings, cis-Methyl 2,2-diMethyl-3-hydroxycyclobutanecarboxylate is employed as a model compound to study various chemical reactions and mechanisms, furthering the understanding of organic chemistry and potentially leading to the discovery of new synthetic pathways and applications.

Upstream product

• 288848-24-8 (1S,3R)-3-acetyl-2,2-dimethylcyclobutane carboxylic acid 
• 80-57-9 (-)-Verbenone 
• 136780-45-5 methyl (1S,3R)-3-acetyl-2,2-dimethylcyclobutanecarboxylate 
• 527751-14-0 (1S,3R)-3-Acetoxy-2,2-dimethyl-cyclobutanecarboxylic acid methyl ester 

Downstream Products

• 527751-17-3 (1S)-methyl 2,2-dimethyl-3-oxocyclobutanecarboxylate 

Relevant academic research and scientific papers

Differential oxidation conditions of substituted cyclobutanols derived from terpenes

The use of different oxidants for homochiral cyclobutanols afforded dissimilar products depending on the agent used. Dess-Martin periodinane allowed us to obtain the homochiral cyclobutanones and sodium hypochlorite produced only one of the two possible regioisomeric γ-butyrolactones. Copyright

Efficient synthesis of chiral Δ2-1,3,4-thiadiazolines from α-pinene and verbenone

The synthesis of chiral cyclobutane 1,3,4-thiadiazoline derivatives starting from (-)-α-pinene and (-)-verbenone was studied. The diastereoisomeric excesses of the products obtained depended strongly upon the starting chiral ketone. The stereochemical assignments of the synthesized compounds were performed by NMR spectroscopy, X-ray analysis, and theoretical calculations.

Stereoselective synthesis of chiral precursors to cyclobutane carbocyclic nucleosides and oligopeptides

Versatile and highly efficient synthetic routes leading to optically active cyclobutanones, γ-amino acids and δ-amino alcohols are described. These compounds are relevant synthetic precursors to enantiopure cyclobutane carbocyclic nucleosides and oligopeptides. (-)-(S)-Verbenone is the chiral starting material used and the key synthetic steps involve concerted rearrangements in acidic medium.