527751-17-3

Upstream product

• 26189-59-3 1-chloro-1-(dimethylamino)-2-methyl-1-propene 
• 292638-85-8 acrylic acid methyl ester 
• 1392804-41-9 (1S,3R)-methyl 3-hydroxy-2,2-dimethylcyclobutanecarboxylate 
• 136780-45-5 methyl (1S,3R)-3-acetyl-2,2-dimethylcyclobutanecarboxylate 
• 527751-14-0 (1S,3R)-3-Acetoxy-2,2-dimethyl-cyclobutanecarboxylic acid methyl ester 
• 80-57-9 (-)-Verbenone 
• 288848-24-8 (1S,3R)-3-acetyl-2,2-dimethylcyclobutane carboxylic acid 

Downstream Products

• 1434141-90-8 tert-butyl (2,2-dimethyl-3-oxocyclobutyl)carbamate 
• 1434141-79-3 tert-butyl (3-hydroxy-2,2-dimethylcyclobutyl)carbamate 
• 1434247-99-0 3-amino-2,2-dimethylcyclobutanol 
• 308287-86-7 (3-amino-2,2-dimethylcyclobutyl)methanol 
• 1392803-57-4 tert-butyl (3-amino-2,2-dimethylcyclobutyl)carbamate 
• 188918-39-0 3-((tert-butoxycarbonyl)amino)-2,2-dimethylcyclobutanecarboxylic acid 

Relevant academic research and scientific papers

Discovery of the Selective Protein Kinase C-θ Kinase Inhibitor, CC-90005

The PKC-θ isoform of protein kinase C is selectively expressed in T lymphocytes and plays an important role in the T cell antigen receptor (TCR)-triggered activation of mature T cells, T cell proliferation, and the subsequent release of cytokines such as

HETEROARYLDIHYDROPYRIMIDINE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

Provided herein are compounds useful for the treatment of HBV infection in a subject in need thereof, pharmaceutical compositions thereof, and methods of inhibiting, suppressing, or preventing HBV infection in the subject.

Synthesis and spectroscopic characterization of cyclobutyl hydantoins

The hydantoin moiety has proved to be an important pharmacophore that confers a wide range of biological properties to different derivatives. Thus, synthetic methods have been developed to obtain such molecules. Herein, we describe the heterocyclization process to obtain imidazolidine-2,4-diones (hydantoin compounds) from methylcyclobutyl ketones and cyclobutanones derived from (?)-(1S)-α-pinene and (?)-(1S)-verbenone through the Bucherer-Berg reaction. The methylcyclobutyl hydantoins and the spirohydantoin obtained were fully characterized, determining their absolute stereochemistry by nuclear magnetic resonance experiments and theoretical calculations.

SUBSTITUTED DIAMINOPYRIMIDYL COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH

Provided herein are diaminopyrimidyl Compounds having the following structures: wherein X, L, R1, and R2 are as defined herein, compositions comprising an effective amount of a Diaminopyrimidyl Compound, and methods for treating or preventing PKC-theta-mediated disorders, or a condition treatable or preventable by inhibition of a kinase, for example, PKC-theta.

Differential oxidation conditions of substituted cyclobutanols derived from terpenes

The use of different oxidants for homochiral cyclobutanols afforded dissimilar products depending on the agent used. Dess-Martin periodinane allowed us to obtain the homochiral cyclobutanones and sodium hypochlorite produced only one of the two possible regioisomeric γ-butyrolactones. Copyright

Efficient synthesis of chiral Δ2-1,3,4-thiadiazolines from α-pinene and verbenone

The synthesis of chiral cyclobutane 1,3,4-thiadiazoline derivatives starting from (-)-α-pinene and (-)-verbenone was studied. The diastereoisomeric excesses of the products obtained depended strongly upon the starting chiral ketone. The stereochemical assignments of the synthesized compounds were performed by NMR spectroscopy, X-ray analysis, and theoretical calculations.

A Practical synthesis of 3-Acyl cyclobutanones by [2 〈 2] annulation. Mechanism and utility of the zn(II)-Catalyzed condensation of r-Chloroenamines with electron-deficient alkenes

New conditions for the conversion of simple tertiary amides to R-chloroenamines and their use in Zn(II)-catalyzed cycloaddition reactions with commercial α,β-unsaturated carbonyl compounds allows rapid, regiocontrolled access to 3-acyl cyclobutanones. Rea

Stereoselective synthesis of chiral precursors to cyclobutane carbocyclic nucleosides and oligopeptides

Versatile and highly efficient synthetic routes leading to optically active cyclobutanones, γ-amino acids and δ-amino alcohols are described. These compounds are relevant synthetic precursors to enantiopure cyclobutane carbocyclic nucleosides and oligopeptides. (-)-(S)-Verbenone is the chiral starting material used and the key synthetic steps involve concerted rearrangements in acidic medium.