139285-95-3Relevant academic research and scientific papers
Synthesis and Some Reactions of 4-Aroyl-6-arylpyridazine-3-(2H)-ones
Mustafa, O. E. A.,Derbala, H. A. Y.,Emara, S. A.,Sallam, H. A.,Ismail, M. Fekry
, p. 175 - 186 (2007/10/03)
4-Aroyl-6-p-tolylpyridazine-3(2H)-ones (2a and b) were prepared by the oxidation of the corresponding 4-benzyl derivatives (3a and b) using sodium dichromate in glacial acetic acid. Compounds (2a and b) underwent normal condensation reactions of ketones with hydrazine hydrate and 2,4-dinitrophenyl-hydrazine to give the corresponding hydrazones (5a-c) and with hydroxylamine hydrochloride to give the oximes (5d and e). 2a and b) reacted with dimethylsulphate to give 6a and b. The reaction of (2a and b) with formaldehyde in the presence of secondary amines gave the Mannich bases (8a-d). The pyridazinones (2a and b) underwent a Michael type addition to acrylonitrile to give (9a and b), respectively. The alkaline hydrolysis of (9b) affected complete cleavage of the cyanoethyl group yielding the aroylpyridazinone (2b).
Novel Synthesis of 4-Aroyl-6-phenylpyridazin-3(2H)-ones
Ismail, M. F.,Sayed, F. S.,Emara, S. A.,Shindy, A. A.
, p. 1720 - 1722 (2007/10/02)
4-Aroyl-6-phenylpyridazin-3(2H)-ones, 1H NMR Spectra4-Aroyl-6-phenylpyridazin-3(2H)-ones (4a-c) were synthesized by the oxidation of the corresponding 4-arylmethyl-6-phenylpyridazin-3(2H)-ones (3a-c) using sodium dichromate in glacial acetic acid.The reac
