20153-14-4

Upstream product

• 77811-91-7 5-Phenyl-3-[1-phenyl-meth-(E)-ylidene]-1-{[1-phenyl-meth-(E)-ylidene]-amino}-1,3-dihydro-pyrrol-2-one 
• 77811-88-2 1-acetylamino-4-benzylidene-5-oxo-2-phenyl-Δ²-pyrroline 
• 4361-96-0 3-benzylidene-5-phenylfuran-2(3H)-one 
• 127157-60-2 2-benzyl-2-hydroxy-4-oxo-4-phenyl-butyric acid 
• 77811-61-1 4-Oxo-4-phenyl-2-[1-phenyl-meth-(Z)-ylidene]-butyric acid [1-phenyl-meth-(E)-ylidene]-hydrazide 
• 57999-71-0 α-Phenacyl-zimtsaeure-hydrazid 
• 100-52-7 benzaldehyde 
• 53949-11-4 γ-phenyl-α-phenylmethylene-Δ^β,γ-butenolide 
• 77811-89-3 N-Acetyl-N-{2-oxo-5-phenyl-3-[1-phenyl-meth-(E)-ylidene]-2,3-dihydro-pyrrol-1-yl}-acetamide 
• 77811-93-9 (E)-4-Phenyl-2-[1-phenyl-meth-(E)-ylidene]-4-{N'-[1-phenyl-meth-(Z)-ylidene]-hydrazino}-but-3-enoic acid 

Downstream Products

• 139285-95-3 4-benzoyl-6-phenylpyridazine-3(2H)-one 
• 64657-83-6 4-benzyl-3-chloro-6-phenylpyridazine 
• 118269-81-1 (4-Benzyl-6-phenyl-pyridazin-3-yl)-(2-morpholin-4-yl-ethyl)-amine; hydrochloride 
• 64657-99-4 ethyl 2-(5-benzyl-6-oxo-3-phenylpyridazin-1(6H)-yl)acetate 
• 1350839-60-9 4-benzyl-6-phenyl-2-[3-(4-phenylpiperazin-1-yl)propyl]-2H-pyridazin-3-one 
• 1350839-68-7 4-benzyl-2-[3-(4-benzylpiperazin-1-yl)propyl]-6-phenyl-2H-pyridazin-3-one 
• 1350839-76-7 4-benzyl-2-[3-(4-ethylpiperazin-1-yl)propyl]-6-phenyl-2H-pyridazin-3-one 
• 1350839-80-3 4-benzyl-2-(3-morpholin-4-ylpropyl)-6-phenyl-2H-pyridazin-3-one 
• 1350839-84-7 4-benzyl-2-{3-[4-(3-chlorophenyl)piperazin-1-yl]propyl}-6-phenyl-2H-pyridazin-3-one 

Relevant academic research and scientific papers

Synthesis and preliminary evaluation activity studies of novel 4-(aryl/heteroaryl-2-ylmethyl)-6-phenyl-2-[3-(4-substitutedpiperazine-1-yl) propyl]pyridazin-3(2H)-one derivatives as anticancer agents

A series of new 4-(aryl/heteroaryl-2-ylmethyl)- 6-phenyl-2-[3-(4- substituted piperazine-1-yl)propyl] pyridazin- 3(2H)-one derivatives were synthesized. The structures of the compounds were confirmed by IR, 1H NMR, and mass spectral data. All the compounds were evaluated for their cytotoxicity toward five human cancer cell lines of different origins viz; HeLa (Cervical), SKBR3 (Breast), HCT116 (Colon), A375 (Skin) & H1299 (Lung) at different concentrations and the IC50 values were determined. HCT116 and HeLa are the most sensitive against the compounds studied. One of them displayed moderate cytotoxicity against SKBR3. Majority of the compounds exhibited good to moderate activity.

Synthesis of some pyridazinylacetic acid derivatives as a novel class of monoamine oxidase-A inhibitors

A series of new pyridazinylacetic acid derivatives were synthesized and have been investigated for their ability to inhibit the activity of the A and B isoforms of monoamine oxidase (MAO). All compounds were found to be more selective to the MAO-A isoform with compound 5d having the highest SI values. Computational study performed with a docking technique indicated the potential of these compounds in pyridazine-based MAO-A inhibitor drug development.

3-Aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities

Minaprine [3[(β-morpholinoethyl)amino]4-methyl-6-phenylpyridazine dihydrochloride] is active in most animal models of depression and exhibits in vivo a dual dopaminomimetic and serotoninomimetic activity profile. In an attempt to dissociate these two effe

Conversion of α-Arylidene-γ-phenyl-Δβ,γ-butenolides into Nitrogen Heterocycles

Treatment of α-arylidene-γ-phenyl-Δβ,γ-butenolides (I) with strong nucleophiles brings about opening of the γ-lactone ring with the formation of acyclic acid derivatives (II).The acid hydrazides (IIa-d) undergo facile condensation with carbonyl