1392888-98-0

Basic information

• Product Name: C₂₄H₃₂N₈S
• CAS NO: 1392888-98-0
• Molecular Weight: 464.638
• Mol File: 1392888-98-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₂N₈S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₂N₈S(1392888-98-0)
• EPA Substance Registry System: C₂₄H₃₂N₈S(1392888-98-0)

Safety Data

• Hazardous Substances Data: 1392888-98-0(Hazardous Substances Data)

Upstream product

• 138022-02-3 4-[(methylamino)methyl]piperidine-1-carboxylic acid tert-butyl ester 
• 1336911-04-6 C₁₇H₁₇ClN₆S 

Relevant articles and documents

Pyrimidinopyrimidine inhibitors of ketohexokinase: Exploring the ring C2 group that interacts with Asp-27B in the ligand binding pocket

Inhibitors of ketohexokinase (KHK) have potential for the treatment of diabetes and obesity. We have continued studies on a pyrimidinopyrimidine series of potent KHK inhibitors by exploring the 2-position substituent (R 3) that interacts with Asp-27B in the ATP-binding region of KHK (viz. 1, 2; Table 1). We found that increased spacing between the terminal ammonium group and the heterocyclic scaffold (viz. 16-20), such that interaction with Asp-27B is not possible, still results in potent KHK inhibition (IC50 = 15-50 nM). We propose a new interaction with Asp-194, which serves to expand the pyrimidinopyrimidine pharmacophore.