139297-17-9Relevant articles and documents
Preparation, structural analysis and anticonvulsant activity of 3- and 5-aminopyrazole N-benzoyl derivatives
Michon,Herve du Penhoat,Tombret,Gillardin,Lepage,Berthon
, p. 147 - 155 (1995)
Some unsymmetrical N-exocyclic and N-endocyclic derivatives from benzoylation of 3- and 5-aminopyrazole were prepared with the aim of comparing their anticonvulsant activity towards the MES and scMET tests. Unambiguous proof of their structure was obtained from heteronuclear long-range correlation spectroscopy and NOE difference spectra. Only the N-exo-pyrazole benzamides showed good protection with respect to these tests.
3-Isoxazoyl derivatives endowed with anticonvulsant activity, procedure for their preparation and their pharmaceutical compositions
-
, (2008/06/13)
The object of the invention is heterocyclic compounds of general formula (I) endowed with anticonvulsant activity: STR1 in which Y is selected from --O--, --S-- and STR2 R4 being H or optionally substituted alkyl, acyl or benzyl, Z is selected