165333-66-4

Upstream product

• 31230-17-8 3-methyl-5-aminopyrazole 
• 21900-37-8 2,6-dimethylbenzoyl chloride 
• 35100-92-6 1,5-dimethyl-1H-pyrazol-3-ylamine 
• 75-09-2 dichloromethane 
• 139297-17-9 N-(1,5-dimethylpyrazol-3-yl)-2,6-dimethylbenzamide 

Relevant academic research and scientific papers

N(pyrazol-3-yl) benzamides and pharmaceutical compositions

The invention relates to a compound useful for treating epilepsy selected from the compounds of the general formula: STR1 in which R1 is C1 -C4 alkyl, R2 is C1 -C4 alkyl, R3 is selected from hydrogen, C1 -C4 alkyl, C1 -C4 alkoxy and C1 -C4 hydroxyalkyl, and R4 is selected from hydrogen, C1 -C4 alkyl, C2 -C7 alkanoyl and C1 -C4 hydroxyalkyl.

Preparation, structural analysis and anticonvulsant activity of 3- and 5-aminopyrazole N-benzoyl derivatives

Some unsymmetrical N-exocyclic and N-endocyclic derivatives from benzoylation of 3- and 5-aminopyrazole were prepared with the aim of comparing their anticonvulsant activity towards the MES and scMET tests. Unambiguous proof of their structure was obtained from heteronuclear long-range correlation spectroscopy and NOE difference spectra. Only the N-exo-pyrazole benzamides showed good protection with respect to these tests.