165333-66-4Relevant articles and documents
Preparation, structural analysis and anticonvulsant activity of 3- and 5-aminopyrazole N-benzoyl derivatives
Michon,Herve du Penhoat,Tombret,Gillardin,Lepage,Berthon
, p. 147 - 155 (2007/10/02)
Some unsymmetrical N-exocyclic and N-endocyclic derivatives from benzoylation of 3- and 5-aminopyrazole were prepared with the aim of comparing their anticonvulsant activity towards the MES and scMET tests. Unambiguous proof of their structure was obtained from heteronuclear long-range correlation spectroscopy and NOE difference spectra. Only the N-exo-pyrazole benzamides showed good protection with respect to these tests.