139308-01-3Relevant academic research and scientific papers
A stereocontrolled method for the synthesis of each of the four diastereomers of 34-dialkyl-substituted β-lactams using different metal ester enolates and a chiral imine
Fujisawa, Tamotsu,Ichikawa, Mitsuhiro,Ukaji, Yutaka,Shimizu, Makoto
, p. 1307 - 1310 (2007/10/02)
The reaction of the different metal ester enolates of t-butyl α-alkyl substituted acetates with a chiral imine possessing a dioxolane ring derived from (2S,3S)-1,4-dimethoxy-2,3-butanediol as a chiral auxiliary followed by cyclization of the initial produ
Diastereoface-discrimination reaction of lithium or titanium ester enolates with a chiral imine leading to stereodivergent synthesis of β-lactams
Fujisawa, Tamotsu,Ukaji, Yutaka,Noro, Tomohiro,Date, Kengo,Shimizu, Makoto
, p. 5629 - 5638 (2007/10/02)
Diastereoselective addition reaction of ester enolates to a chiral imine possessing (4S, 5S)-4,5-dimethoxymethyl-2-methyl-1,3-dioxolane ring as a chiral auxiliary is reported, in which varying metal enolates resulted in the selective formation of (4S)- or
A stereodivergent construction of β-lactam skeletons via condensation of ester enolates and a chiral imine
Fujisawa, Tamotsu,Ukaji, Yutaka,Noro, Tomohiro,Date, Kengo,Shimizu, Makoto
, p. 7563 - 7566 (2007/10/02)
Diastereofacial selectivity in an addition reaction of ester enolates to a chiral imine with 1,3-dioxolane, derived from (S,S)-1,4-dimethoxy-2,3-butanediol as a chiral auxiliary, could be fully regulated by the appropriate selection of metal enolates used. Addition of the lithium enolates provided (4S)-β-lactams, while the corresponding (4R)-β-lactams were obtained by the condensation of titanium enolates with the chiral imine.
