139308-07-9

Upstream product

• 3289-28-9 ethyl cyclohexanecarboxylate 
• 139308-00-2 (4S,5S)-4,5-Dimethoxymethyl-2-(N-p-methoxyphenyl)iminomethyl-2-methyl-1,3-dioxolane 
• 143658-94-0 (4S,5S)-2-formyl-2-methyl-4,5-dimethoxymethyl-1,3-dioxolane 
• 139308-13-7 (4S,5S)-2-hydroxymethyl-2-methyl-4,5-dimethoxy-1,3-dioxolane 
• 50622-10-1 (-)-(2S,3S)-1,4-dimethoxy-2,3-butanediol 

Relevant academic research and scientific papers

Diastereoface-discrimination reaction of lithium or titanium ester enolates with a chiral imine leading to stereodivergent synthesis of β-lactams

Diastereoselective addition reaction of ester enolates to a chiral imine possessing (4S, 5S)-4,5-dimethoxymethyl-2-methyl-1,3-dioxolane ring as a chiral auxiliary is reported, in which varying metal enolates resulted in the selective formation of (4S)- or

A stereodivergent construction of β-lactam skeletons via condensation of ester enolates and a chiral imine

Diastereofacial selectivity in an addition reaction of ester enolates to a chiral imine with 1,3-dioxolane, derived from (S,S)-1,4-dimethoxy-2,3-butanediol as a chiral auxiliary, could be fully regulated by the appropriate selection of metal enolates used. Addition of the lithium enolates provided (4S)-β-lactams, while the corresponding (4R)-β-lactams were obtained by the condensation of titanium enolates with the chiral imine.