1393123-09-5Relevant articles and documents
Metal-free oxidative fluorination of phenols with [18F]fluoride
Gao, Zhanghua,Lim, Yee Hwee,Tredwell, Matthew,Li, Lei,Verhoog, Stefan,Hopkinson, Matthew,Kaluza, Wojciech,Collier, Thomas Lee,Passchier, Jan,Huiban, Mickael,Gouverneur, Véronique
, p. 6733 - 6737 (2012/08/28)
The radiochemical synthesis of [18F]4-fluorophenols is based on phenol umpolung under oxidative conditions and direct nucleophilic fluorination with [18F]fluoride (see scheme, TBAF=tetra-n-butylammonium fluoride, TFA=trifluoroacetic acid). Readily available O-unprotected 4-tert-butyl phenols are used as precursors in this one-pot protocol. The reaction is completed in less than 30 minutes at room temperature and can be performed using standard or microfluidic technology. Copyright
