1393330-36-3 Usage
Uses
Used in Bioconjugation and Drug Synthesis:
Bromo-PEG1-t-butyl ester is used as a bioconjugation agent for the attachment of various molecules, such as drugs, peptides, or other biomolecules, to PEG chains. The bromide group facilitates nucleophilic substitution reactions, enabling the formation of stable covalent bonds with target molecules, which can improve their solubility, stability, and bioavailability.
Used in Drug Delivery Systems:
In the pharmaceutical industry, Bromo-PEG1-t-butyl ester is used as a component in the design of drug delivery systems. The PEG linker can be utilized to modify drug molecules, enhancing their circulation time in the body and reducing their immunogenicity. Additionally, the t-butyl protected carboxyl group allows for the controlled release of the drug under specific conditions, such as in response to a change in pH or the presence of specific enzymes.
Used in Diagnostic Imaging:
Bromo-PEG1-t-butyl ester can be employed as a contrast agent in diagnostic imaging techniques, such as magnetic resonance imaging (MRI) or computed tomography (CT). The PEG linker can be functionalized with imaging agents, improving their solubility and circulation time in the body, leading to enhanced imaging results.
Used in Material Science:
In the field of material science, Bromo-PEG1-t-butyl ester can be used as a building block for the development of novel materials with specific properties. The PEG linker can be incorporated into polymers, hydrogels, or other structures, providing enhanced solubility, biocompatibility, and tunable degradation rates.
Used in Chemical Synthesis:
Bromo-PEG1-t-butyl ester serves as an intermediate in the synthesis of various complex molecules, such as pharmaceuticals, agrochemicals, or specialty chemicals. The bromide group can be replaced by a wide range of nucleophiles, allowing for the introduction of diverse functional groups and the creation of a vast array of products with different applications.
Check Digit Verification of cas no
The CAS Registry Mumber 1393330-36-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,9,3,3,3 and 0 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1393330-36:
(9*1)+(8*3)+(7*9)+(6*3)+(5*3)+(4*3)+(3*0)+(2*3)+(1*6)=153
153 % 10 = 3
So 1393330-36-3 is a valid CAS Registry Number.
1393330-36-3Relevant articles and documents
BIFUNCTIONAL DEGRADERS OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES AND THERAPEUTIC USE THEREOF
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Page/Page column 112, (2021/08/27)
The present disclosure provides bifunctional compounds as IRAK4 degraders via ubiquitin proteasome pathway, and method for treating diseases modulated by IRAK4.
BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF
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Page/Page column 73-74, (2021/11/13)
The present disclosure provides bifunctional compounds as HPK1 degraders via ubiquitin proteosome pathway, and method for treating diseases modulated by HPK1.
PCSK9 ANTAGONIST COMPOUNDS
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Page/Page column 117-118, (2020/01/12)
Disclosed are compounds of Formula I, or a salt thereof: where A, B, D, X, R1, R2 and R8 are as defined herein, which compounds have properties for antagonizing PCSK9. Also described are pharmaceutical formulations comprising the compounds of Formula I or their salts, and methods of treating cardiovascular disease and conditions related to PCSK9 activity, e.g. atherosclerosis, hypercholesterolemia, coronary heart disease, metabolic syndrome, acute coronary syndrome, or related cardiovascular disease and cardiometabolic conditions.
