1393370-57-4

Basic information

• Product Name: 1,1-bis(4-fluorophenyl)-4-phenylbut-2-yne-1,4-diol
• Synonyms: 1,1-bis(4-fluorophenyl)-4-phenylbut-2-yne-1,4-diol
• CAS NO: 1393370-57-4
• Molecular Weight: 350.365
• Mol File: 1393370-57-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1,1-bis(4-fluorophenyl)-4-phenylbut-2-yne-1,4-diol(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-bis(4-fluorophenyl)-4-phenylbut-2-yne-1,4-diol(1393370-57-4)
• EPA Substance Registry System: 1,1-bis(4-fluorophenyl)-4-phenylbut-2-yne-1,4-diol(1393370-57-4)

Safety Data

• Hazardous Substances Data: 1393370-57-4(Hazardous Substances Data)

Upstream product

• 357-77-7 1,1-bis(4-fluorophenyl)prop-2-yn-1-ol 
• 100-52-7 benzaldehyde 
• 345-92-6 4,4'-Difluorobenzophenone 

Downstream Products

• 1393371-13-5 2,3-bis(4-fluorophenyl)-5-phenylfuran 
• 1393370-75-6 (4-(2,2-bis(4-fluorophenyl)vinyl)-2,5-diphenylfuran-3-yl)(phenyl)methanone 

Relevant articles and documents

Bronsted acid-catalyzed cycloisomerization of but-2-yne-1,4-diols with or without 1,3-dicarbonyl compounds to tri- and tetrasubstituted furans

A Bronsted acid-catalyzed method to prepare tri- and tetrasubstituted furans efficiently from cycloisomerization of but-2-yne-1,4-diols with or without 1,3-dicarbonyl compounds is described. By taking advantage of the orthogonal modes of reactivity of the alcoholic substrate through slight modification of the reaction conditions, a divergence in product selectivity was observed. At room temperature, p-TsOH?H 2O-mediated tandem alkylation/cycloisomerization of the propargylic 1,4-diol with the β-dicarbonyl compound was found to selectively occur to provide the tetrasubstituted furan product. On the other hand, increasing the reaction temperature to 80 °C was discovered to result in preferential p-TsOH?H2O-catalyzed dehydrative rearrangement of the unsaturated alcohol and formation of the 2,3,5-trisubstituted furan adduct.