139338-97-9

Upstream product

• 139339-00-7 4-methylamino-3-nitro-1-phenyl-1,8-naphthyridin-2(1H)-one 
• 139338-98-0 4-hydroxy-3-nitro-1-phenyl-1,8-naphthyridin-2(1H)-one 
• 139338-99-1 4-chloro-3-nitro-1-phenyl-1,8-naphthyridin-2(1H)-one 
• 138305-19-8 1-phenyl-2H-pyrido<2,3-d><1,3>oxazine-2,4(1H)-dione 
• 122-51-0 orthoformic acid triethyl ester 

Relevant academic research and scientific papers

Imidazonaphthyridine derivatives

Disclosed are imidazonaphthyridine derivatives represented by formula (I) STR1 wherein: R1 represents lower alkyl or substituted or unsubstituted aryl; and X-Y-Z represents STR2 wherein R2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C (R5) H--(CH2)n --R4 (wherein R4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR6 R7 wherein R6 and R7 independently represents hydrogen or lower alkyl; R5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryl and pharmaceutically acceptable sails thereof. The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.

A Facile and Novel Synthesis of 5-Phenylimidazonaphthyridin-4(5H)-ones

A convenient and regioselective synthesis of a new heterocycle, 5-phenyl-1H or 3H-imidazonaphthyridin-4(5H)-one 1-a or 1-b, is described.Methyl 2-anilinonicotinate 15 was transformed into the valuable intermediate, N-phenyl-3-azaisatoic anhydr