139339-01-8

Usage

Chemical class

Naphthyridines

Core structure

Naphthyridinone

Amino group

At the 4-position

Nitro group

At the 3-position

Phenyl group

At the 1-position

Applications

Organic synthesis and medicinal chemistry

Pharmaceutical development

Used for developing various pharmaceuticals and agrochemicals

Biological activities

a. Anti-inflammatory
b. Anti-bacterial
c. Anti-cancer

Importance

Key molecule in drug discovery and development

Therapeutic applications

Studied for potential use in treating various diseases and disorders

Upstream product

• 138305-19-8 1-phenyl-2H-pyrido<2,3-d><1,3>oxazine-2,4(1H)-dione 
• 139338-98-0 4-hydroxy-3-nitro-1-phenyl-1,8-naphthyridin-2(1H)-one 
• 139338-99-1 4-chloro-3-nitro-1-phenyl-1,8-naphthyridin-2(1H)-one 

Downstream Products

• 160623-93-8 3,4-diamino-1-phenyl-1,8-naphthyridin-2(1H)-one 
• 139339-02-9 5-phenyl-1H-imidazo<4,5-c><1,8>naphthyridin-4(5H)-one 
• 139360-51-3 3-methyl-5-phenyl-3H-imidazo<4,5-c><1,8>naphthyridin-4(5H)-one 
• 139339-09-6 3-Ethyl-5-phenyl-3H-imidazo[4,5-c][1,8]naphthyridin-4(5H)-one 
• 139339-10-9 3-Isopropyl-5-phenyl-3,5-dihydro-1,3,5,6-tetraaza-cyclopenta[a]naphthalen-4-one 
• 139339-11-0 3-benzyl-5-phenyl-3H-imidazo[4,5-c][1,8]naphthyridin-4(5H)-one 
• 139482-62-5 3-benzyl-2,5-diphenyl-3H-imidazo<4,5-c><1,8>naphthyridin-4(5H)-one 
• 139482-61-4 3-benzyl-2-methyl-5-phenyl-3H-imidazo<4,5-c><1,8>naphthyridin-4(5H)-one 
• 139482-20-5 2,5-diphenyl-3H-imidazo<4,5-c><1,8>naphthyridin-4(5H)-one 
• 139482-19-2 2-methyl-5-phenyl-3H-imidazo<4,5-c><1,8>naphthyridin-4(5H)-one 

Relevant academic research and scientific papers

Imidazonaphthyridine derivatives

The present invention relates to novel imidazonaphthyridine derivatives represented by the following formulae: STR1 wherein R represents hydrogen, lower alkyl or --CH2 R1 (where R1 represents phenyl or pyridyl) and pharmac

Imidazonaphthyridine derivatives

Disclosed are imidazonaphthyridine derivatives represented by formula (I) STR1 wherein: R1 represents lower alkyl or substituted or unsubstituted aryl; and X-Y-Z represents STR2 wherein R2 represents hydrogen, lower alkyl, alkenyl, aralkenyl, or --C (R5) H--(CH2)n --R4 (wherein R4 represents substituted or unsubstituted aryl, substituted or unsubstituted pyridyl, substituted or unsubstituted furyl, hydroxy-substituted lower alkyl, lower alkanoyloxy, morpholino, lower alkanoyl, carboxy, lower alkoxycarbonyl, cycloalkyl, hydroxy, lower alkoxy, halogen or NR6 R7 wherein R6 and R7 independently represents hydrogen or lower alkyl; R5 represents hydrogen, lower alkyl, or phenyl; and n represents an integer of 0 to 3); and R3 represents hydrogen, mercapto, hydroxy, lower alkyl, or aryl and pharmaceutically acceptable sails thereof. The compounds show a potent anti-inflammatory, anti-allergic and broncho-dilative activity.

A Facile and Novel Synthesis of 5-Phenylimidazonaphthyridin-4(5H)-ones

A convenient and regioselective synthesis of a new heterocycle, 5-phenyl-1H or 3H-imidazonaphthyridin-4(5H)-one 1-a or 1-b, is described.Methyl 2-anilinonicotinate 15 was transformed into the valuable intermediate, N-phenyl-3-azaisatoic anhydr