1393442-03-9

Upstream product

• 106-47-8 4-chloro-aniline 
• 5398-77-6 para-methanesulfonylbenzaldehyde 
• 1392200-85-9 N¹-(6-chloro-2-methylquinolin-4-yl)-N²,N²-dimethylethane-1,2-diamine 
• 187386-90-9 C₁₂H₁₄ClNO₂ 
• 15644-86-7 6-chloro-2-methyl-quinolin-4-ol 
• 53342-53-3 4,6-dichloro-2-methylquinoline 

Relevant academic research and scientific papers

Design, synthesis and cytotoxicity of novel 2-arylvinyl-4- aminoquinoline derivatives

With an aim to develop promising anti-tumor agents, a novel series of 2-arylvinyl-4-aminoquinoline derivatives were designed, synthesized and evaluated for their cytotoxicity against H-460, HT-29, HepG2 and SGC-7901 cell lines in vitro. The pharmacological results indicated that most compounds were more potent than the positive controls, especially compounds 8, 14 and 16 with IC50 values ranging from 0.05 to 0.85 μM against all tested cell lines respectively, which were 5.7- to 112-fold better than Iressa. The most active compound 14 (IC50 values of 0.05, 0.25, 0.16, 0.68 μM), bearing 4-fluorostyryl at C-2 position and 3-(dimethylamino)-1-propylamino at C-4 position, showed great promise as a lead for the development of more effective quinoline analogues.