139348-99-5

Upstream product

• 94-09-7 p-aminoethylbenzoate 
• 139348-98-4 ethyl 4-(4-chlorobutyrylamino)benzoate 
• 86364-65-0 ethyl <2-oxo-1-pyrrolidinyl>benzoate 
• 95-92-1 oxalic acid diethyl ester 

Downstream Products

• 139348-91-7 N-<4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoyl>-L-glutamic acid 
• 139349-01-2 4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoic acid 
• 139349-00-1 ethyl 4-<3-(3-amino-2,5-dihydro-5-oxo-1,2,4-triazin-6-yl)-2-oxo-1-pyrrolidinyl>benzoate 

Relevant academic research and scientific papers

Synthesis and biological activity of open-chain analogues of 5,6,7,8- tetrahydrofolic acid-potential antitumor agents

This study describes the synthesis and in vitro antitumor activity of inhibitors of purine de novo biosynthesis that are analogues of N-[4-[[3- (2,4-diamino-1,6-dihydro-6-oxo-5-pyrimidinyl)propyl]amino]benzoyl-L-glutamic acid (5-DACTHF). Benzene ring subs