1393601-98-3

Upstream product

• 858-98-0 3-benzyloxyestra-1,3,5⁽¹⁰⁾-trien-17-one 
• 624-38-4 para-diiodobenzene 
• 1393601-94-9 7α-propoxy-17α-ethynylestra-1,3,5(10)-trien-3,17β-diol 
• 1393601-90-5 3-O-(tert-butyldimethylsilyl)-7α-propoxyestra-1,3,5(10)-trien-3-ol-17-one 
• 1393601-88-1 7α-propoxyestra-1,3,5(10)-trien-3-ol-17-one 
• 1393601-86-9 7α-propoxyestra-1,3,5(10)-trien-3-ol-17-one-17,17-(2'-[5',5'-dimethyl-1',3'-dioxane]) 
• 1393601-81-4 3-O-benzyl-6α,7α-epoxyestra-1,3,5(10)-trien-3-ol-17-one-17,17-(2'-[5',5'-dimethyl-1',3'-dioxane]) 
• 1393601-80-3 3-O-benzyl-estra-1,3,5⁽¹⁰⁾,6⁽⁷⁾-tetraen-3-ol-17-one-17,17-(2'-[5',5'-dimethyl-1',3'-dioxane]) 
• 1393601-79-0 3-O-benzyl-estra-1,3,5⁽¹⁰⁾-triene-3,6-diol-17-one-17,17-(2'-[5',5'-dimethyl-1',3'-dioxane]) 
• 1393601-78-9 3-O-benzyl-6-oxoestra-1,3,5⁽¹⁰⁾-triene-3-ol-17-one-17,17-(2'-[5',5'-dimethyl-1',3'-dioxane]) 
• 1393601-77-8 3-O-benzyl-estra-1,3,5⁽¹⁰⁾-trien-3-ol-17-one-17,17-(2'-[5',5'-dimethyl-1',3'-dioxane]) 

Relevant academic research and scientific papers

Novel 7α-alkoxy-17α-(4′-halophenylethynyl)estradiols as potential SPECT/PET imaging agents for estrogen receptor expressing tumours: Synthesis and binding affinity evaluation

In order to develop potential radiolabelled probes for imaging estrogen receptor (ER) positive tumours, we have synthesized and characterized a series of novel 7α-alkoxy-17α-(4′-iodophenylethynyl)estra-1,3,5(10)- triene-3,17β-diols and 7α-alkoxy-17α-(4′- fluorophenylethynyl)estra-1,3,5(10)-triene-3,17β-diols. The fluoro-substituted compounds showed a higher ER binding affinity than the corresponding iodo-derivatives, where 7α-methoxy- and 17α-(4′- fluorophenylethynyl)estra-1,3,5(10)-triene-3,17β-diol showed the highest ER binding affinities (RBA = 80.9% and 78.9%, respectively), among the halophenylethynyl compounds studied and should be further explored as potential PET biomarkers for imaging of ER expressing tumours.