1393647-06-7Relevant articles and documents
Synthesis, Spectroscopic Studies of Fluorinated Pyrimido-1,2,4-Triazines: Protective Effect Against Some Plant Pathogenic Fungi
Aqlan, Faisal M. S.,Makki, Mohammed S. T.,Abdel-Rahman, Rada M.
, p. 1310 - 1317 (2016)
In search for new biologically active compounds, several new fluorine-substituted pyrimido [2,3-c][1,2,4]triazino (3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16) have been synthesized via the nucleophilic attack of 2-hydrazinopyrimidinone (2) toward more positive carbons under different conditions. Structure of the newly synthesized compounds was deduced from elemental analyses as well as their spectral data (UV, IR, NMR, and M/S). The antifungal activity of the target ring systems has been evaluated both in vitro and in vivo against some phytopathogenic fungi associated with wheat grains. Result showed that compounds 6, 7, and 8 have high protection of wheat grains against the fungal infection.
Novel pyrimidinone derivatives: Synthesis, antitumor and antimicrobial evaluation
Taher, Azza,Helwa, Amira Atef
experimental part, p. 521 - 530 (2012/06/01)
Starting from 6-aryl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5- carbonitrile (4a-d), a series of mono- and dialkyl derivatives 5a-j and 6a, b was synthesized. Hydrazinolysis of 4a, b, d and 5d afforded the hydrazino derivatives 7a-c which were cyclised to give the triazolopyrimidinones 8a-c and the pyrimidotriazinones 9a-c through the reaction with formic acid and chloroacetyl chloride, respectively. Most of the newly synthesized compounds were evaluated for their in-vitro antitumor activity. Compounds 6a and b displayed promising anticancer activity against leukaemia, non-small cell lung, melanoma, and renal cancer. On the other hand, all compounds prepared were screened for their in-vitro antibacterial and antifungal activities. Compounds 5h and j showed significant activity against Staphylococcus aureus, while compounds 5e, 7c and 8c displayed moderate inhibitory activity against Candida albicans.
