1393647-08-9

Basic information

• Product Name: 5-(4-fluorophenyl)-7-oxo-1,7-dihydro-[1,2,4]triazolo[4,3-a]-pyrimidine-6-carbonitrile
• CAS NO: 1393647-08-9
• Molecular Weight: 255.211
• Mol File: 1393647-08-9.mol

Chemical Properties

• CAS DataBase Reference: 5-(4-fluorophenyl)-7-oxo-1,7-dihydro-[1,2,4]triazolo[4,3-a]-pyrimidine-6-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-fluorophenyl)-7-oxo-1,7-dihydro-[1,2,4]triazolo[4,3-a]-pyrimidine-6-carbonitrile(1393647-08-9)
• EPA Substance Registry System: 5-(4-fluorophenyl)-7-oxo-1,7-dihydro-[1,2,4]triazolo[4,3-a]-pyrimidine-6-carbonitrile(1393647-08-9)

Safety Data

• Hazardous Substances Data: 1393647-08-9(Hazardous Substances Data)

Upstream product

• 131364-75-5 6-(4-fluorophenyl)-4-oxo-2-sulfanylidene-1,2,3,4-tetrahydropyrimidine-5-carbonitrile 
• 459-57-4 4-fluorobenzaldehyde 
• 1393646-97-3 2-(ethylthio)-4-(4-f luorophenyl)-6-oxo-1,6-dihydropyrimidine-5-carbonitrile 
• 64-18-6 formic acid 
• 1393647-06-7 6-(4-fluorophenyl)-2-hydrazinyl-4-oxo-1,4-dihydropyrimidine-5-carbonitrile 

Relevant articles and documents

Novel pyrimidinone derivatives: Synthesis, antitumor and antimicrobial evaluation

Starting from 6-aryl-4-oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5- carbonitrile (4a-d), a series of mono- and dialkyl derivatives 5a-j and 6a, b was synthesized. Hydrazinolysis of 4a, b, d and 5d afforded the hydrazino derivatives 7a-c which were cyclised to give the triazolopyrimidinones 8a-c and the pyrimidotriazinones 9a-c through the reaction with formic acid and chloroacetyl chloride, respectively. Most of the newly synthesized compounds were evaluated for their in-vitro antitumor activity. Compounds 6a and b displayed promising anticancer activity against leukaemia, non-small cell lung, melanoma, and renal cancer. On the other hand, all compounds prepared were screened for their in-vitro antibacterial and antifungal activities. Compounds 5h and j showed significant activity against Staphylococcus aureus, while compounds 5e, 7c and 8c displayed moderate inhibitory activity against Candida albicans.