1393686-89-9

Usage

Uses

Used in Pharmaceutical Synthesis:
Thiazole-4,5-diyldimethanol is used as a building block for the development of various pharmaceuticals, leveraging its unique chemical structure to create novel compounds with potential therapeutic applications.
Used in Agrochemical Development:
In the agrochemical industry, Thiazole-4,5-diyldimethanol is utilized as a key component in the synthesis of new agrochemicals, contributing to the creation of innovative products for crop protection and enhancement of agricultural yields.
Used in Materials Science:
Thiazole-4,5-diyldimethanol is employed as a fundamental component in the field of materials science, where it aids in the development of advanced materials with specific properties tailored for various applications.
Used in Antimicrobial Applications:
Due to its potential antimicrobial properties, Thiazole-4,5-diyldimethanol is used as an active ingredient in products designed to inhibit the growth of microorganisms, finding applications in healthcare, food preservation, and other industries where microbial control is essential.
Used in Antioxidant Formulations:
Leveraging its antioxidant potential, Thiazole-4,5-diyldimethanol is used in the formulation of products that protect against oxidative damage, which is crucial in various industrial processes and in the development of health supplements.
Used in Metal Coordination Chemistry:
As a chelating agent, Thiazole-4,5-diyldimethanol is used in metal coordination chemistry to form complexes with metal ions, which is vital for applications in catalysis, environmental remediation, and the development of new materials with unique properties.

Upstream product

• 18940-72-2 diethyl thiazole-4,5-dicarboxylate 

Downstream Products

• 1393686-90-2 5-(4-nitrophenyl)sulfonyl-4,6-dihydropyrrolo[3,4-d]thiazole 

Relevant academic research and scientific papers

Structure-based lead optimization to improve antiviral potency and ADMET properties of phenyl-1H-pyrrole-carboxamide entry inhibitors targeted to HIV-1 gp120

We are continuing our concerted effort to optimize our first lead entry antagonist, NBD-11021, which targets the Phe43 cavity of the HIV-1 envelope glycoprotein gp120, to improve antiviral potency and ADMET properties. In this report, we present a structure-based approach that helped us to generate working hypotheses to modify further a recently reported advanced lead entry antagonist, NBD-14107, which showed significant improvement in antiviral potency when tested in a single-cycle assay against a large panel of Env-pseudotyped viruses. We report here the synthesis of twenty-nine new compounds and evaluation of their antiviral activity in a single-cycle and multi-cycle assay to derive a comprehensive structure-activity relationship (SAR). We have selected three inhibitors with the high selectivity index for testing against a large panel of 55 Env-pseudotyped viruses representing a diverse set of clinical isolates of different subtypes. The antiviral activity of one of these potent inhibitors, 55 (NBD-14189), against some clinical isolates was as low as 63 nM. We determined the sensitivity of CD4-binding site mutated-pseudoviruses to these inhibitors to confirm that they target HIV-1 gp120. Furthermore, we assessed their ADMET properties and compared them to the clinical candidate attachment inhibitor, BMS-626529. The ADMET data indicate that some of these new inhibitors have comparable ADMET properties to BMS-626529 and can be optimized further to potential clinical candidates.

A facile synthesis of 5,6-dihydro-4H-pyrrolo[3,4-d]thiazole and other pyrrolidine-fused aromatic ring systems via one-step cyclization from diols

A facile synthetic method of 5,6-dihydro-4H-pyrrolo[3,4-d]thiazole, which is a subunit of a potent factor Xa (fXa) inhibitor was developed. This new approach employs one-step cyclization from a diol and can be applied to the syntheses of other pyrrolidine-fused aromatic ring sytems.