1393723-77-7

Basic information

• Product Name: (R)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)-3-(3'-(trifluoromethyl)biphenyl-4-yl)propanoic acid
• CAS NO: 1393723-77-7
• Molecular Weight: 563.554
• Mol File: 1393723-77-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)-3-(3'-(trifluoromethyl)biphenyl-4-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)-3-(3'-(trifluoromethyl)biphenyl-4-yl)propanoic acid(1393723-77-7)
• EPA Substance Registry System: (R)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)-3-(3'-(trifluoromethyl)biphenyl-4-yl)propanoic acid(1393723-77-7)

Safety Data

• Hazardous Substances Data: 1393723-77-7(Hazardous Substances Data)

Upstream product

• 62561-75-5 (R)-2-amino-3-(4-iodophenyl)propanoic acid 
• 3563-14-2 4-{3-carboxy-propionylamino}-benzene-1-sulfonamide 
• 1393723-69-7 (R)-methyl 3-(4-iodophenyl)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)propanoate 
• 1423-26-3 (meta-(trifluoromethyl)phenyl)boronic acid 
• 372967-43-6 (R)-methyl 2-amino-3-(4-iodophenyl)propanoate 

Relevant articles and documents

Discovery of small-molecule interleukin-2 inhibitors from a DNA-encoded chemical library

Libraries of chemical compounds individually coupled to encoding DNA tags (DNA-encoded chemical libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNAencoded chemical library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments. High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic analysis of selection strategies and statistically robust identification of binding molecules. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by molecular docking. Our findings suggest that DNA-encoded chemical libraries allow the facile identification of drug-like ligands principally to any protein of choice, including molecules capable of disrupting high-affinity protein-protein interactions.