372967-43-6

Basic information

• Product Name: (R)-methyl 2-amino-3-(4-iodophenyl)propanoate
• Synonyms: (R)-methyl 2-amino-3-(4-iodophenyl)propanoate
• CAS NO: 372967-43-6
• Molecular Weight: 305.115
• Mol File: 372967-43-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-methyl 2-amino-3-(4-iodophenyl)propanoate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-methyl 2-amino-3-(4-iodophenyl)propanoate(372967-43-6)
• EPA Substance Registry System: (R)-methyl 2-amino-3-(4-iodophenyl)propanoate(372967-43-6)

Safety Data

• Hazardous Substances Data: 372967-43-6(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 62561-75-5 (R)-2-amino-3-(4-iodophenyl)propanoic acid 

Downstream Products

• 1393723-74-4 (R)-3-(biphenyl-4-yl)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)propanoic acid 
• 1393723-75-5 (R)-3-(2',4'-difluorobiphenyl-4-yl)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)propanoic acid 
• 1393723-76-6 (R)-3-(3',4'-dichlorobiphenyl-4-yl)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)propanoic acid 
• 1393723-77-7 (R)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)-3-(3'-(trifluoromethyl)biphenyl-4-yl)propanoic acid 
• 1393723-78-8 (R)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)-3-(4'-(trifluoromethyl)biphenyl-4-yl)propanoic acid 
• 1393723-69-7 (R)-methyl 3-(4-iodophenyl)-2-(4-oxo-4-(4-sulfamoylphenylamino)butanamido)propanoate 
• 210962-92-8 tert-butyl [(2R)-1-hydroxy-3-(4-iodophenyl)propan-2-yl]carbamate 
• 1426129-50-1 N-[(1R)-2-[1,1'-biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid tert-butyl ester 
• 113850-76-3 (R)-2-((tert-butoxycarbonyl)amino)-3-(4-iodophenyl)propanoate 

Relevant articles and documents

Discovery of small-molecule interleukin-2 inhibitors from a DNA-encoded chemical library

Libraries of chemical compounds individually coupled to encoding DNA tags (DNA-encoded chemical libraries) hold promise to facilitate exceptionally efficient ligand discovery. We constructed a high-quality DNAencoded chemical library comprising 30 000 drug-like compounds; this was screened in 170 different affinity capture experiments. High-throughput sequencing allowed the evaluation of 120 million DNA codes for a systematic analysis of selection strategies and statistically robust identification of binding molecules. Selections performed against the tumor-associated antigen carbonic anhydrase IX (CA IX) and the pro-inflammatory cytokine interleukin-2 (IL-2) yielded potent inhibitors with exquisite target specificity. The binding mode of the revealed pharmacophore against IL-2 was confirmed by molecular docking. Our findings suggest that DNA-encoded chemical libraries allow the facile identification of drug-like ligands principally to any protein of choice, including molecules capable of disrupting high-affinity protein-protein interactions.