1393726-74-3

Basic information

• Product Name: 6-(4-bromobenzyl)-8,8-difluoro-1,6-naphthyridine-5,7(6H,8H)-dione
• Synonyms: 6-(4-bromobenzyl)-8,8-difluoro-1,6-naphthyridine-5,7(6H,8H)-dione
• CAS NO: 1393726-74-3
• Molecular Weight: 367.149
• Mol File: 1393726-74-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 6-(4-bromobenzyl)-8,8-difluoro-1,6-naphthyridine-5,7(6H,8H)-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 6-(4-bromobenzyl)-8,8-difluoro-1,6-naphthyridine-5,7(6H,8H)-dione(1393726-74-3)
• EPA Substance Registry System: 6-(4-bromobenzyl)-8,8-difluoro-1,6-naphthyridine-5,7(6H,8H)-dione(1393726-74-3)

Safety Data

• Hazardous Substances Data: 1393726-74-3(Hazardous Substances Data)

Upstream product

• 20577-26-8 2-bromonicotinonitrile 
• 1393726-72-1 8,8-difluoro-1,6-naphthyridine-5,7(6H,8H)-dione 
• 589-15-1 1-bromomethyl-4-bromobenzene 
• 1393726-71-0 ethyl (3-cyanopyridin-2-yl)difluoroacetate 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 

Relevant articles and documents

Synthesis of gem-difluorinated 1,6-naphthyridine-5,7-diones

A synthetic route toward new 8,8-difluoro-1,6-naphthyridine-5,7-diones, which are of interest as new building blocks in pharmaceutical chemistry, is described. The key steps include a copper-mediated cross-coupling of ethyl bromodifluoroacetate and 2-bromo-3-cyanopyridine, followed by hydrolysis of the nitrile function and subsequent cyclization.