1393748-64-5

Basic information

• Product Name: 17a-aza-17a-benzoyl-3-cyano-17a-homoandrosta-3,5-dien-17-one
• Synonyms: 17a-aza-17a-benzoyl-3-cyano-17a-homoandrosta-3,5-dien-17-one
• CAS NO: 1393748-64-5
• Molecular Weight: 414.547
• Mol File: 1393748-64-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 17a-aza-17a-benzoyl-3-cyano-17a-homoandrosta-3,5-dien-17-one(CAS DataBase Reference)
• NIST Chemistry Reference: 17a-aza-17a-benzoyl-3-cyano-17a-homoandrosta-3,5-dien-17-one(1393748-64-5)
• EPA Substance Registry System: 17a-aza-17a-benzoyl-3-cyano-17a-homoandrosta-3,5-dien-17-one(1393748-64-5)

Safety Data

• Hazardous Substances Data: 1393748-64-5(Hazardous Substances Data)

Upstream product

• 7680-15-1 3β-hydroxy-13α-amino-13,17-seco-5-androsten-17-oic-13,17-lactam 
• 84368-89-8 3β-acetoxy-androst-5-en-17-one oxime 
• 1600-81-3 (10aR,12aS)-10a,12a-dimethyl-4,4a,4b,5,6,9,10,10a,10b,11,12,12a-dodecahydronaphtho[2,1-f]quinoline-2,8(1H,3H)-dione 
• 2232-16-8 3-acetoxy-17a-aza-17a-homo-androst-5-en-17-one 
• 853-23-6 prasterone acetate 
• 1393748-55-4 17a-aza-3-cyano-17a-homoandrosta-3,5-dien-17-one 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Synthesis and biological evaluation of novel unsaturated carboxysteroids as human 5α-reductase inhibitors: A legitimate approach

In the present study, novel steroidal 17a-substituted 3-cyano-17a-aza-D- homo-3,5-androstadien-17-ones (12-19) and 17a-substituted 17-oxo-17a-aza-D-homo- 3,5-androstadien-3-oic acids (20-26) were synthesized from dehydroepiandrosterone acetate (6) along with 17-oxo-19-nor-3,5-androstadien-3- oic acid (30) through a multistep synthesis. Compounds were evaluated for their in vitro 5α-reductase inhibitory activity by measuring the conversion of [3H] androstenedione in human embryonic kidney (HEK) cells. In vivo 5α-reductase inhibitory activity was also determined using rat prostate weighing method. Compounds 21-23 and 25 showed potent inhibition of 5α-reductase II enzyme with IC50 values of 54.1 ± 9.5, 22.1 ± 2.4, 72.8 ± 2.3 and 26.5 ± 4.4 nM respectively as compared to Finasteride (30.3 nM) along with a significant (p 0.05) reduction in rat prostate weight.