1393802-40-8

Basic information

• Product Name: (R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester
• Synonyms: (R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester
• CAS NO: 1393802-40-8
• Molecular Weight: 365.417
• Mol File: 1393802-40-8.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester(1393802-40-8)
• EPA Substance Registry System: (R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester(1393802-40-8)

Safety Data

• Hazardous Substances Data: 1393802-40-8(Hazardous Substances Data)

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 1606166-80-6 (R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide 
• 445-27-2 2'-Fluoroacetophenone 
• 557-20-0 diethylzinc 

Relevant articles and documents

COMBINATION TREATMENT COMPRISING ADMINISTRATION OF 2-AMINO-3,5,5-TRIFLUORO-3,4,5,6-TETRAHYDROPYRIDINES

The present invention is directed to the combined use of BACE1 inhibitor of Formula (I) and a compound useful in active or passive Tau immunotherapy, a compound useful in active or passive Aβ peptide immunotherapy, an NMDA receptor antagonists, an acetylcholine esterase inhibitor, an antiepileptic, an anti-inflammatory drug, a Tau aggregation inhibitor or an SSRI for the treatment of neurodegenerative or cognitive disorders.

1,4-OXAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS

This invention relates to compounds of the formula wherein and R1 to R3 are as described herein, or to pharmaceutically acceptable salts thereof. These compounds are BACE1 and/or BACE2 inhibitors and can be used as pharmaceuticals fo