(R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester

Base Information

Chemical Name:(R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester
CAS No.:1393802-40-8
Molecular Formula:C₁₆H₂₂F₃NO₃S
Molecular Weight:365.417
Hs Code.:

Synonyms:(R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester

Chemical Property:

Purity/Quality:

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Technology Process of (R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester

There total 4 articles about (R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 667-27-6
Ethyl bromodifluoroacetate

: 1606166-80-6
(R)-N-[1-(2-fluorophenyl)ethylidene]-2-methyl-propane-2-sulfinamide

: 1393802-40-8
(R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester

Guidance literature:: With Wilkinson's catalyst; diethylzinc; In tetrahydrofuran; hexane; at 0 - 20 ℃; Inert atmosphere; Molecular sieve;

Reference yield:

: 667-27-6
Ethyl bromodifluoroacetate

: (R)-N-(1-(2-fluorophenyl)ethylidene)-2-methylpropane-2-sulfinamide

: 557-20-0
diethylzinc

: 1393802-40-8
(R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester

Guidance literature:: With tris(triphenylphosphine)rhodium(I) chloride; SiO₂; In tetrahydrofuran; hexane; ethyl acetate;

Reference yield:

: 445-27-2
2'-Fluoroacetophenone

: 1393802-40-8
(R)-2,2-difluoro-3-(2-fluorophenyl)-3-(R)-2-methylpropane-2-sulfinylaminobutyric acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: SiO₂ / tetrahydrofuran; ethyl acetate

2: tris(triphenylphosphine)rhodium(I) chloride; SiO₂ / tetrahydrofuran; ethyl acetate; hexane

With tris(triphenylphosphine)rhodium(I) chloride; SiO₂; In tetrahydrofuran; hexane; ethyl acetate;