1393883-03-8

Basic information

• Product Name: C₂₅H₁₈F₂N₆
• CAS NO: 1393883-03-8
• Molecular Weight: 440.455
• Mol File: 1393883-03-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₅H₁₈F₂N₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₁₈F₂N₆(1393883-03-8)
• EPA Substance Registry System: C₂₅H₁₈F₂N₆(1393883-03-8)

Safety Data

• Hazardous Substances Data: 1393883-03-8(Hazardous Substances Data)

Upstream product

• 423183-90-8 2-(4-fluorophenyl)quinoline-4,6-diamine 
• 1416440-17-9 C₁₅H₈ClFN₂O₂ 
• 1416439-28-5 C₁₅H₉FN₂O₃ 
• 403-42-9 1-(4-fluorophenyl)ethanone 
• 1999-00-4 ethyl 3-(4'-fluorophenyl)-3-oxopropionate 
• 98305-74-9 2-amino-6-(4'-fluorophenyl)-pyrimidin-4-ol 

Relevant articles and documents

Quinolinyl pyrimidines: Potent inhibitors of NDH-2 as a novel class of anti-TB agents

NDH-2 is an essential respiratory enzyme in Mycobacterium tuberculosis (Mtb), which plays an important role in the physiology of Mtb. Herein, we present a target-based effort to identify a new structural class of inhibitors for NDH-2. High-throughput screening of the AstraZeneca corporate collection resulted in the identification of quinolinyl pyrimidines as the most promising class of NDH-2 inhibitors. Structure-activity relationship studies showed improved enzyme inhibition (IC50) against the NDH-2 target, which in turn translated into cellular activity against Mtb. Thus, the compounds in this class show a good correlation between enzyme inhibition and cellular potency. Furthermore, early ADME profiling of the best compounds showed promising results and highlighted the quinolinyl pyrimidine class as a potential lead for further development.