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98305-74-9

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98305-74-9 Usage

Class

Pyrimidine

Functional Groups

4-amino-3-hydroxy-2-propen-1-one group
4-fluorophenyl group
Amino group

Bioactivity

Potential antineoplastic and antiviral properties

Research Applications

Pharmaceutical research
Synthesis of complex chemical compounds

Protein Target Inhibition

Studied as an inhibitor of various protein targets

Interest in Drug Design and Discovery

Due to its potential pharmacological properties

Check Digit Verification of cas no

The CAS Registry Mumber 98305-74-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 9,8,3,0 and 5 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 98305-74:
(7*9)+(6*8)+(5*3)+(4*0)+(3*5)+(2*7)+(1*4)=159
159 % 10 = 9
So 98305-74-9 is a valid CAS Registry Number.

98305-74-9SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-amino-6-(4-fluorophenyl)-1H-pyrimidin-4-one

1.2 Other means of identification

Product number -
Other names 4(1H)-Pyrimidinone,2-amino-6-(4-fluorophenyl)

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:98305-74-9 SDS

98305-74-9Relevant articles and documents

Synthesis and Investigation of Phthalazinones as Antitubercular Agents

Santoso, Kristiana T.,Cheung, Chen-Yi,Hards, Kiel,Cook, Gregory M.,Stocker, Bridget L.,Timmer, Mattie S. M.

supporting information, p. 1278 - 1285 (2019/02/24)

A series of 2- and 7-substituted phthalazinones was synthesised and their potential as anti-tubercular drugs assessed via Mycobacterium tuberculosis (mc26230) growth inhibition assays. All phthalazinones tested showed growth inhibitory activity (MIC 100 μm), and those compounds containing lipophilic and electron-withdrawing groups generally exhibited better anti-tubercular activity. Several lead compounds were identified, including 7-((2-amino-6-(4-fluorophenyl)pyrimidin-4-yl)amino)-2-heptylphthalazin-1(2H)-one (MIC=1.6 μm), 4-tertbutylphthalazin-2(1H)-one (MIC=3 μm), and 7-nitro-phthalazin-1(2H)-one (MIC=3 μm). Mode of action studies indicated that selected pyrimidinyl-phthalazinones may interfere with NADH oxidation, however, the mode of action of the lead compound is independent of this enzyme. MIC=minimum inhibitory concentration.

NOVEL PYRIMIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND COMPOSITIONS CONTAINING THEM

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Page/Page column 284, (2008/06/13)

The present invention provides new heterocyclic compounds, particularly substituted pyrimidines, methods and compositions for making and using these heterocyclic compounds, and methods for treating a variety of diseases and disease states, including atherosclerosis, arthritis, restenosis, diabetic nephropathy, or dyslipidemia, or disease states mediated by the low expression of Perlecan.

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