1393902-34-5Relevant academic research and scientific papers
I2/TBPB mediated oxidative reaction of aryl acetaldehydes with amidines: Synthesis of 1,2,5-triaryl-1H-imidazoles
Wang, Jing,Zhang, Fang-Dong,Tang, Dong,Wu, Ping,Zhang, Xue-Guo,Chen, Bao-Hua
, p. 24594 - 24597 (2017/07/11)
A direct method for the synthesis of 1,2,5-triaryl-1H-imidazoles was achieved easily from cyclization of aryl acetaldehydes with amidines catalyzed by I2. Various substitued groups can be employed, and this reaction proceeds smoothly in moderate to good yields.
Ambivalent role of metal chlorides in ring opening reactions of 2H-azirines: Synthesis of imidazoles, pyrroles and pyrrolinones
Auricchio, Sergio,Truscello, Ada M.,Lauria, Mirvana,Meille, Stefano V.
experimental part, p. 7441 - 7449 (2012/09/22)
2H-Azirines were found to react with imines, enaminones and enaminoesters in the presence of metal salts. Imidazoles, pyrroles and new pyrrolinones derivatives are isolated in good overall yields. The role of metal salts was investigated as they can act as Lewis acids or electron donors. Mechanisms are proposed suggesting that imidazoles arise from addition of azirine to imines via radical or ionic mechanism; pyrroles and pyrrolinones are obtained from azirines with enamino derivatives when the salt acts as a Lewis acid. In the latter case the properties of the metallic compound influence the reaction regioselectivity.
