1393904-01-2

Basic information

• Product Name: N-((1H-indol-3-yl)(phenyl)methyl)pyridin-2-amine
• Synonyms: N-((1H-indol-3-yl)(phenyl)methyl)pyridin-2-amine
• CAS NO: 1393904-01-2
• Molecular Weight: 299.375
• Mol File: 1393904-01-2.mol

Chemical Properties

• CAS DataBase Reference: N-((1H-indol-3-yl)(phenyl)methyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-((1H-indol-3-yl)(phenyl)methyl)pyridin-2-amine(1393904-01-2)
• EPA Substance Registry System: N-((1H-indol-3-yl)(phenyl)methyl)pyridin-2-amine(1393904-01-2)

Safety Data

• Hazardous Substances Data: 1393904-01-2(Hazardous Substances Data)

Upstream product

• 504-29-0 2-aminopyridine 
• 120-72-9 indole 
• 100-52-7 benzaldehyde 

Relevant articles and documents

Natural Products for Drug Discovery: Discovery of Gramines as Novel Agents against a Plant Virus

Plant viral diseases seriously affect crop yield and quality. The natural product gramine (1) and its simple structural analogues 2-35 were synthesized from indoles, amines, and aldehydes in one step. The antiviral effects of these alkaloids were evaluated systematically. Most of these compounds were found to have higher antiviral effects than commercial ribavirin for the first time. Especially compounds 22, 30, and 31 exhibited significantly higher effects than ningnanmycin, thereby emerging as novel antiviral leads for further optimization. The preliminary implementation indicated that these compounds likely inhibit the assembly of tobacco mosaic virus (TMV) by cross-linking TMV capsid protein. Gramine analogues were also found to have broad-spectrum fungicidal effects. Although gramine has been reported to have influence on germination and development of Erysiphe graminis, these compounds displayed no fungicidal effects against Blumeria graminis f. sp. tritici on wheat in our test. Some of these compounds also exhibited certain insecticidal activities.

Heterocycle-functional gramine analogues: Solvent- and catalyst-free synthesis and their inhibition activities against cell proliferation

A series of novel gramine analogues were designed and synthesized via a convenient three-component reaction, and which were evaluated for their inhibition activities against cell proliferation. Their structures were confirmed by satisfactory spectra analyses mainly including 1H NMR, and ESI-MS analyses. The preliminary assays indicated that some of the newly synthesized compounds displayed significantly good inhibition activities against human lung cancer (NCI-H460), hepatocellular liver carcinoma (HepG2), gastric cancer (SGC-7901 and BGC-823) cell lines compared with the control 5-Fluorouracil (5-FU), which might be developed as novel lead scaffold for potential anticancer agents.