1394015-00-9

Upstream product

• 610271-66-4 dimethyl 2-[(dimethylamino)methylidene]-3-oxopentane-1,5-dioate 
• 80421-15-4 1,6-Dihydro-4-hydroxy-6-oxo-1-phenyl-3-pyridincarbonsaeure-methylester 
• 1394014-75-5 C₁₉H₁₄ClNO₃ 
• 1394014-63-1 C₂₀H₁₇NO₆S 
• 1830-54-2 3-oxopentanedioic acid dimethyl ester 
• 80421-14-3 dimethyl 3-oxo-2-[(phenylamino)methylene]glutarate 
• 109-55-7 1-amino-3-(dimethylamino)propane 
• 1394014-89-1 C₁₈H₁₂ClNO₃ 

Relevant academic research and scientific papers

Diversity-oriented synthesis of 1-substituted 4-aryl-6-oxo-1,6- dihydropyridine-3-carboxamides.

A simple five-step diversity-oriented synthesis of 1-substituted 4-aryl-6-oxo-1,6-dihydropyridine-3-carboxamides was developed. Treatment of dimethyl 2-((dimethylamino)methylidene)-3-oxopentanedioate with twenty primary amines gave 1-substituted methyl 4-hydroxy-6-oxo-1,6-dihydropyridine-3- carboxylates. Transformation into the corresponding 4-tosyloxy and 4-chloro derivatives, followed by Suzuki-Miyaura arylations gave a series of eleven N-substituted methyl 4-aryl-6-oxo-1,6-dihydropyridine-3-carboxylates. Combinatorial screening was employed to establish suitable reaction conditions for Suzuki-Miyaura arylation of N-alkylpyridones. Hydrolysis of the esters followed by parallel solution-phase amidation of the corresponding carboxylic acids with primary and secondary amines furnished a library of seventeen final products.